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AgelessRx vs Twentyeight Health: Which Is Better?

Head-to-head comparison of AgelessRx and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 73.4/100), leading on trust & safety, value, experience. AgelessRx comes out ahead on product range.

73

AgelessRx is an Ann Arbor-based longevity telehealth company that prescribes rapamycin, metformin, low-dose naltrexone and NAD+, and also sells compounded and branded GLP-1s.

Visit AgelessRx
75

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health

Score Breakdown

DimensionAgelessRxTwentyeight Health
Overall Score73.4/10075/100 ✓
Trust & Safety30%72/10076/100 ✓
Value25%74/10080/100 ✓
Experience20%70/10072/100 ✓
Product Range15%82/100 ✓72/100
Reputation10%70/10070/100

At a Glance

Founded20192018
HeadquartersAnn Arbor, MIBrooklyn, NY
Publicly tradedNoNo
Treatment categories44
Treatments listed147
Starting price$25/mo$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryAgelessRxTwentyeight Health
Weight Loss / GLP-1$99
Microdosing Semaglutide
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Women's Health—$15–$19.99
Complete Care Membership

AgelessRx

+Deepest longevity formulary we track: rapamycin ($65/mo), metformin and LDN ($25/mo), NAD+, sermorelin, glutathione and B12
+Research-led: publishes a named medical director and runs its own decentralised trials (e.g. PEARL rapamycin study)
+Low entry prices with video visits and shipping included and no separate membership fee
−No consolidated price list; GLP-1 and NAD+ prices vary widely by plan length ($79 vs $235/mo reported for NAD+ injections)
−Headline microdosed tirzepatide price ($159/mo) requires a four-month plan billed upfront (~$636)
−Reviewers report slow support replies, billing/card-decline errors and heavy marketing email
Read the full AgelessRx review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

AgelessRx vs Twentyeight Health — FAQ

Is AgelessRx better than Twentyeight Health?

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Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 73.4/100), leading on trust & safety, value, experience. AgelessRx comes out ahead on product range.

Is AgelessRx or Twentyeight Health cheaper?

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Twentyeight Health has the lower starting price (from $15/mo vs $25/mo for AgelessRx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do AgelessRx and Twentyeight Health both offer?

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Both platforms treat Weight Loss / GLP-1, Women's Health. AgelessRx covers 4 treatment categories total and Twentyeight Health covers 4.

Still deciding?

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