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altRx vs Twentyeight Health: Which Is Better?

Head-to-head comparison of altRx and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 47.6/100), leading on trust & safety, value, experience, product range, reputation.

48
altRx
Below Average

altRx is a Miami-operated, GLP-1-only telehealth brand advertising compounded semaglutide from $89/mo and tirzepatide from $149/mo with no separate membership fee.

Visit altRx
75

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health

Score Breakdown

DimensionaltRxTwentyeight Health
Overall Score47.6/10075/100 ✓
Trust & Safety30%42/10076/100 ✓
Value25%70/10080/100 ✓
Experience20%35/10072/100 ✓
Product Range15%50/10072/100 ✓
Reputation10%30/10070/100 ✓

At a Glance

Founded—2018
HeadquartersMiami, FLBrooklyn, NY
Publicly tradedNoNo
Treatment categories14
Treatments listed27
Starting price$89/mo$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryaltRxTwentyeight Health
Weight Loss / GLP-1$89–$159
Compounded Semaglutide (injectable)
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altRx

+Advertised compounded GLP-1 pricing ($89/mo semaglutide, $149/mo tirzepatide) is near the bottom of the market, with no separate membership fee
+Names its four fulfilling pharmacies (RedRock, Health Warehouse, Precision Medicine, Triad Rx) on its site
+Offers branded Wegovy, Zepbound and Ozempic prescriptions alongside compounded options
−Received an FDA warning letter (June 8, 2026) over labeling that misidentified the compounder and 'clinically proven' claims implying FDA approval
−Roughly 73-78% of Trustpilot reviews are one-star, citing undelivered refills, refused refunds, and unanswered phones and email
−Trustpilot has removed reviews on its profile for guideline breaches
Read the full altRx review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

altRx vs Twentyeight Health — FAQ

Is altRx better than Twentyeight Health?

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Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 47.6/100), leading on trust & safety, value, experience, product range, reputation.

Is altRx or Twentyeight Health cheaper?

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Twentyeight Health has the lower starting price (from $15/mo vs $89/mo for altRx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do altRx and Twentyeight Health both offer?

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Both platforms treat Weight Loss / GLP-1. altRx covers 1 treatment category total and Twentyeight Health covers 4.

Still deciding?

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