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Calibrate vs Defy Medical: Which Is Better?

Head-to-head comparison of Calibrate and Defy Medical based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 66.9/100), leading on value, experience, product range, reputation. Calibrate comes out ahead on trust & safety. Calibrate has the lower entry price (from $25/mo vs $150/mo), so the better value depends on which treatment you need.

67

Calibrate is a year-long metabolic-reset program pairing coaching and biomarker tracking with insurance-navigated branded GLP-1 prescribing — built for members who already have GLP-1 coverage, not cash-pay patients.

Visit Calibrate
72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

Visit Defy Medical

Score Breakdown

DimensionCalibrateDefy Medical
Overall Score66.9/10071.9/100 ✓
Trust & Safety30%76/100 ✓72/100
Value25%58/10060/100 ✓
Experience20%72/10078/100 ✓
Product Range15%60/10078/100 ✓
Reputation10%62/10080/100 ✓

At a Glance

Founded20192011
HeadquartersNew York, NYTampa, FL
Publicly tradedNoNo
Treatment categories13
Treatments listed24
Starting price$25/mo$150/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryCalibrateDefy Medical
Weight Loss / GLP-1$25–$1350
Insurance-Navigated Branded GLP-1
$150–$250
GLP-1 Weight Loss (Semaglutide/Tirzepatide)

Calibrate

+Comprehensive year-long program combining 1:1 coaching, biomarker/lab review, and a connected smart scale alongside GLP-1 prescribing
+Insurance-navigation support aims to get members GLP-1 medication near a $25/month copay when commercial coverage applies
+Strong Trustpilot rating (4.5/5, ~1,200 reviews) with many members reporting 40-70+ lb losses
−Poor fit and high cost for cash-pay patients without GLP-1 insurance coverage — medication bills separately and can approach full brand retail (roughly $1,000+/month) if a plan doesn't cover it
−$199/month program fee requires a 3-month minimum commitment ($597) before month-to-month conversion
−Reports of 3+ week waits for medication-dose changes and inconsistent coach assignment session-to-session
Read the full Calibrate review →

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

Calibrate vs Defy Medical — FAQ

Is Calibrate better than Defy Medical?

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Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 66.9/100), leading on value, experience, product range, reputation. Calibrate comes out ahead on trust & safety. Calibrate has the lower entry price (from $25/mo vs $150/mo), so the better value depends on which treatment you need.

Is Calibrate or Defy Medical cheaper?

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Calibrate has the lower starting price (from $25/mo vs $150/mo for Defy Medical). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Calibrate and Defy Medical both offer?

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Both platforms treat Weight Loss / GLP-1. Calibrate covers 1 treatment category total and Defy Medical covers 3.

Still deciding?

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