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Calibrate vs Twentyeight Health: Which Is Better?

Head-to-head comparison of Calibrate and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 66.9/100), leading on value, product range, reputation.

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Calibrate is a year-long metabolic-reset program pairing coaching and biomarker tracking with insurance-navigated branded GLP-1 prescribing — built for members who already have GLP-1 coverage, not cash-pay patients.

Visit Calibrate
75

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health

Score Breakdown

DimensionCalibrateTwentyeight Health
Overall Score66.9/10075/100 ✓
Trust & Safety30%76/10076/100
Value25%58/10080/100 ✓
Experience20%72/10072/100
Product Range15%60/10072/100 ✓
Reputation10%62/10070/100 ✓

At a Glance

Founded20192018
HeadquartersNew York, NYBrooklyn, NY
Publicly tradedNoNo
Treatment categories14
Treatments listed27
Starting price$25/mo$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryCalibrateTwentyeight Health
Weight Loss / GLP-1$25–$1350
Insurance-Navigated Branded GLP-1
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Calibrate

+Comprehensive year-long program combining 1:1 coaching, biomarker/lab review, and a connected smart scale alongside GLP-1 prescribing
+Insurance-navigation support aims to get members GLP-1 medication near a $25/month copay when commercial coverage applies
+Strong Trustpilot rating (4.5/5, ~1,200 reviews) with many members reporting 40-70+ lb losses
−Poor fit and high cost for cash-pay patients without GLP-1 insurance coverage — medication bills separately and can approach full brand retail (roughly $1,000+/month) if a plan doesn't cover it
−$199/month program fee requires a 3-month minimum commitment ($597) before month-to-month conversion
−Reports of 3+ week waits for medication-dose changes and inconsistent coach assignment session-to-session
Read the full Calibrate review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

Calibrate vs Twentyeight Health — FAQ

Is Calibrate better than Twentyeight Health?

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Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 66.9/100), leading on value, product range, reputation.

Is Calibrate or Twentyeight Health cheaper?

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Twentyeight Health has the lower starting price (from $15/mo vs $25/mo for Calibrate). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Calibrate and Twentyeight Health both offer?

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Both platforms treat Weight Loss / GLP-1. Calibrate covers 1 treatment category total and Twentyeight Health covers 4.

Still deciding?

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