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Defy Medical vs LifeMD: Which Is Better?

Head-to-head comparison of Defy Medical and LifeMD based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 68/100), leading on trust & safety, experience, product range, reputation. LifeMD comes out ahead on value. LifeMD has the lower entry price (from $14/mo vs $150/mo), so the better value depends on which treatment you need.

72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

Visit Defy Medical
68
LifeMD
Good

Publicly traded telehealth betting big on weight loss, with aggressive GLP-1 pricing and fast-growing subscriber base.

Visit LifeMD

Score Breakdown

DimensionDefy MedicalLifeMD
Overall Score71.9/100 ✓68/100
Trust & Safety30%72/100 ✓65/100
Value25%60/10075/100 ✓
Experience20%78/100 ✓70/100
Product Range15%78/100 ✓65/100
Reputation10%80/100 ✓60/100

At a Glance

Founded20112020
HeadquartersTampa, FLNew York, NY
Publicly tradedNoYes (LFMD)
Treatment categories36
Treatments listed45
Starting price$150/mo$14/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDefy MedicalLifeMD
Hormone Therapy$150–$250
Women's Bioidentical HRT
$99
Testosterone Program (via Rex MD)
Weight Loss / GLP-1$150–$250
GLP-1 Weight Loss (Semaglutide/Tirzepatide)
$149–$349
Branded Wegovy (oral/injectable)
Sexual Health—$14–$38
Sildenafil (via Rex MD)

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

LifeMD

+Novo Nordisk partnership for branded Wegovy pill and subscription program
+Eli Lilly partnership for branded Zepbound access
+Publicly traded with quarterly earnings transparency — 25% revenue growth in 2025
−Compounded GLP-1s discontinued — pivoted to branded medications
−Aggressive marketing draws scrutiny from health professionals
−Narrower treatment range than Hims or Ro
Read the full LifeMD review →

Defy Medical vs LifeMD — FAQ

Is Defy Medical better than LifeMD?

▾

Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 68/100), leading on trust & safety, experience, product range, reputation. LifeMD comes out ahead on value. LifeMD has the lower entry price (from $14/mo vs $150/mo), so the better value depends on which treatment you need.

Is Defy Medical or LifeMD cheaper?

▾

LifeMD has the lower starting price (from $14/mo vs $150/mo for Defy Medical). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Defy Medical and LifeMD both offer?

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Both platforms treat Hormone Therapy, Weight Loss / GLP-1, Sexual Health. Defy Medical covers 3 treatment categories total and LifeMD covers 6.

Still deciding?

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