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Defy Medical vs PlushCare: Which Is Better?

Head-to-head comparison of Defy Medical and PlushCare based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 68.3/100), leading on experience, product range, reputation. PlushCare comes out ahead on trust & safety, value. PlushCare has the lower entry price (from $20/mo vs $150/mo), so the better value depends on which treatment you need.

Defy Medical

Good

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

Visit Defy Medical

PlushCare

Good

PlushCare is a virtual primary-care membership service that layers weight-loss visits and branded GLP-1 prescriptions onto its core telehealth offering, rather than running a dedicated compounded-GLP-1 program.

Visit PlushCare

Score Breakdown

Dimension	Defy Medical	PlushCare
Overall Score	71.9/100 ✓	68.3/100
Trust & Safety30%	72/100	78/100 ✓
Value25%	60/100	62/100 ✓
Experience20%	78/100 ✓	62/100
Product Range15%	78/100 ✓	65/100
Reputation10%	80/100 ✓	72/100

At a Glance

Founded	2011	2014
Headquarters	Tampa, FL	San Francisco, CA
Publicly traded	No	No
Treatment categories	3	2
Treatments listed	4	3
Starting price	$150/mo	$20/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

Category	Defy Medical	PlushCare
Weight Loss / GLP-1	$150–$250 GLP-1 Weight Loss (Semaglutide/Tirzepatide)	$650–$1100 Branded GLP-1 Prescription (Wegovy, Saxenda)

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)

+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours

+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing

−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront

−Some patients report delays of a week or more between consult and medication fulfillment

−Mobile app quality lags the web experience, per patient feedback

Read the full Defy Medical review →

PlushCare

+Low $19.99/mo membership with first month free, and insurance-eligible visits as low as a $30 copay

+Accepts major insurance plans (Aetna, Cigna, Humana), broader than most single-purpose GLP-1 telehealth startups

+Physician-led primary care model covers ongoing and chronic care beyond a single weight-loss funnel

−Branded GLP-1 medication (Zepbound, Wegovy) is billed separately at the pharmacy — without insurance coverage this can run roughly $1,000+/month, dwarfing the low membership fee

−No compounded GLP-1 option, so cash-pay patients without drug coverage face full retail brand pricing

−Trustpilot pattern of unexpected recurring membership charges and difficulty cancelling

Read the full PlushCare review →

Defy Medical vs PlushCare — FAQ

Is Defy Medical better than PlushCare?

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Is Defy Medical or PlushCare cheaper?

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PlushCare has the lower starting price (from $20/mo vs $150/mo for Defy Medical). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Defy Medical and PlushCare both offer?

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Both platforms treat Weight Loss / GLP-1. Defy Medical covers 3 treatment categories total and PlushCare covers 2.

Still deciding?

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