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Defy Medical vs Rex MD: Which Is Better?

Head-to-head comparison of Defy Medical and Rex MD based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Rex MD scores higher overall in our independent evaluation (72.2/100 vs 71.9/100), leading on trust & safety, value. Defy Medical comes out ahead on experience, reputation.

72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

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72
Rex MD
Good

Rex MD is a men's-health telehealth brand — owned by publicly traded LifeMD — covering ED, premature ejaculation, TRT, hair loss, and GLP-1 treatment.

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Score Breakdown

DimensionDefy MedicalRex MD
Overall Score71.9/10072.2/100 ✓
Trust & Safety30%72/10078/100 ✓
Value25%60/10065/100 ✓
Experience20%78/100 ✓68/100
Product Range15%78/10078/100
Reputation10%80/100 ✓72/100

At a Glance

Founded20112019
HeadquartersTampa, FLNew York, NY
Publicly tradedNoNo
Treatment categories35
Treatments listed46
Starting price$150/mo$2/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDefy MedicalRex MD
Hormone Therapy$150–$250
Women's Bioidentical HRT
$79–$199
TRT (cypionate/gel/Clomid/sermorelin)
Weight Loss / GLP-1$150–$250
GLP-1 Weight Loss (Semaglutide/Tirzepatide)
$199–$399
GLP-1 Weight Loss
Sexual Health—$2–$90
Sildenafil / Tadalafil (generic & brand)

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

Rex MD

+Backed by LifeMD, a publicly traded parent company, giving it more financial and compliance infrastructure than an independent startup
+Strong Trustpilot rating (4.7/5, 5,259 reviews) with consistent praise for customer service staff
+Wide medication range across ED, premature ejaculation, TRT, hair loss, and GLP-1s under one account
−Recurring patient complaints about surprise auto-renewal charges not clearly disclosed at checkout
−Shipping and fulfillment issues reported, including incorrect dosing and underfilled vials
−Headline 'as low as $2/dose' pricing is a teaser rate; full pricing isn't shown until after intake
Read the full Rex MD review →

Defy Medical vs Rex MD — FAQ

Is Defy Medical better than Rex MD?

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Rex MD scores higher overall in our independent evaluation (72.2/100 vs 71.9/100), leading on trust & safety, value. Defy Medical comes out ahead on experience, reputation.

Is Defy Medical or Rex MD cheaper?

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Rex MD has the lower starting price (from $2/mo vs $150/mo for Defy Medical). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Defy Medical and Rex MD both offer?

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Both platforms treat Hormone Therapy, Weight Loss / GLP-1, Sexual Health. Defy Medical covers 3 treatment categories total and Rex MD covers 5.

Still deciding?

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