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Defy Medical vs Sesame Care: Which Is Better?

Head-to-head comparison of Defy Medical and Sesame Care based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Sesame Care scores higher overall in our independent evaluation (74/100 vs 71.9/100), leading on trust & safety, value. Defy Medical comes out ahead on experience, product range, reputation.

72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

Visit Defy Medical
74

Pay-per-visit marketplace connecting patients with licensed providers — no subscriptions, transparent per-visit pricing.

Visit Sesame Care

Score Breakdown

DimensionDefy MedicalSesame Care
Overall Score71.9/10074/100 ✓
Trust & Safety30%72/10075/100 ✓
Value25%60/10080/100 ✓
Experience20%78/100 ✓70/100
Product Range15%78/100 ✓70/100
Reputation10%80/100 ✓70/100

At a Glance

Founded20112019
HeadquartersTampa, FLNew York, NY
Publicly tradedNoNo
Treatment categories36
Treatments listed45
Starting price$150/mo$34/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDefy MedicalSesame Care
Weight Loss / GLP-1$150–$250
GLP-1 Weight Loss (Semaglutide/Tirzepatide)
$59–$99
Weight Loss Program (subscription)

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

Sesame Care

+No subscription required — pay-per-visit model
+Transparent pricing shown before booking
+Wide range of specialties available
−No integrated pharmacy
−Less continuity of care than subscriptions
−Provider quality varies in marketplace model
Read the full Sesame Care review →

Defy Medical vs Sesame Care — FAQ

Is Defy Medical better than Sesame Care?

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Sesame Care scores higher overall in our independent evaluation (74/100 vs 71.9/100), leading on trust & safety, value. Defy Medical comes out ahead on experience, product range, reputation.

Is Defy Medical or Sesame Care cheaper?

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Sesame Care has the lower starting price (from $34/mo vs $150/mo for Defy Medical). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Defy Medical and Sesame Care both offer?

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Both platforms treat Weight Loss / GLP-1. Defy Medical covers 3 treatment categories total and Sesame Care covers 6.

Still deciding?

Defy Medical alternativesSesame Care alternativesTake the Match Quiz