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Defy Medical vs Shed: Which Is Better?

Head-to-head comparison of Defy Medical and Shed based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 67/100), leading on trust & safety, experience, product range, reputation. Shed comes out ahead on value. Shed has the lower entry price (from $43/mo vs $150/mo), so the better value depends on which treatment you need.

72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

Visit Defy Medical
67
Shed
Good

Weight loss, hair loss, and longevity telehealth with multiple GLP-1 delivery formats including drops, lozenges, and oral tablets.

Visit Shed

Score Breakdown

DimensionDefy MedicalShed
Overall Score71.9/100 ✓67/100
Trust & Safety30%72/100 ✓60/100
Value25%60/10070/100 ✓
Experience20%78/100 ✓70/100
Product Range15%78/100 ✓72/100
Reputation10%80/100 ✓62/100

At a Glance

Founded20112022
HeadquartersTampa, FLGilbert, AZ
Publicly tradedNoNo
Treatment categories32
Treatments listed410
Starting price$150/mo$43/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDefy MedicalShed
Weight Loss / GLP-1$150–$250
GLP-1 Weight Loss (Semaglutide/Tirzepatide)
$115
MIC + B12 Injections

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

Shed

+Widest variety of GLP-1 delivery formats: injections, drops, lozenges, and oral tablets
+Both compounded and brand-name GLP-1 options (Wegovy, Zepbound) available
+10% body weight loss guarantee or money back
−Two-month minimum commitment before cancellation allowed
−Cash-pay only — no insurance accepted
−BBB rating 2.87/5 (not accredited) with billing and cancellation complaints
Read the full Shed review →

Defy Medical vs Shed — FAQ

Is Defy Medical better than Shed?

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Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 67/100), leading on trust & safety, experience, product range, reputation. Shed comes out ahead on value. Shed has the lower entry price (from $43/mo vs $150/mo), so the better value depends on which treatment you need.

Is Defy Medical or Shed cheaper?

▾

Shed has the lower starting price (from $43/mo vs $150/mo for Defy Medical). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Defy Medical and Shed both offer?

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Both platforms treat Weight Loss / GLP-1. Defy Medical covers 3 treatment categories total and Shed covers 2.

Still deciding?

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