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Defy Medical vs SkinnyRx: Which Is Better?

Head-to-head comparison of Defy Medical and SkinnyRx based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 57.9/100), leading on trust & safety, product range, reputation. SkinnyRx comes out ahead on value.

72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

Visit Defy Medical
58

Cash-pay compounded GLP-1 provider offering five dosing formats, currently facing an FDA warning letter against its parent company.

Visit SkinnyRx

Score Breakdown

DimensionDefy MedicalSkinnyRx
Overall Score71.9/100 ✓57.9/100
Trust & Safety30%72/100 ✓45/100
Value25%60/10068/100 ✓
Experience20%78/10078/100
Product Range15%78/100 ✓55/100
Reputation10%80/100 ✓35/100

At a Glance

Founded2011—
HeadquartersTampa, FL—
Publicly tradedNoNo
Treatment categories31
Treatments listed44
Starting price$150/mo$199/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDefy MedicalSkinnyRx
Weight Loss / GLP-1$150–$250
GLP-1 Weight Loss (Semaglutide/Tirzepatide)
$199
Semaglutide Injection

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

SkinnyRx

+Five dosing formats (injection, sublingual, tablet) for semaglutide/tirzepatide give patients flexibility
+Large Trustpilot volume (5,390 reviews) at a 4.8 average suggests broad satisfaction
+Reps cited by name in reviews for responsive onboarding guidance
−FDA warning letter reportedly issued to parent company Lean Rx, Inc. (February 2026) — unverified independently this cycle, needs manual confirmation
−Some patients report oral/sublingual formats were ineffective with no visible results
−A reviewer described being required to pay upfront for medication that had no effect
Read the full SkinnyRx review →

Defy Medical vs SkinnyRx — FAQ

Is Defy Medical better than SkinnyRx?

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Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 57.9/100), leading on trust & safety, product range, reputation. SkinnyRx comes out ahead on value.

Is Defy Medical or SkinnyRx cheaper?

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Defy Medical has the lower starting price (from $150/mo vs $199/mo for SkinnyRx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Defy Medical and SkinnyRx both offer?

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Both platforms treat Weight Loss / GLP-1. Defy Medical covers 3 treatment categories total and SkinnyRx covers 1.

Still deciding?

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