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Defy Medical vs TrimRx: Which Is Better?

Head-to-head comparison of Defy Medical and TrimRx based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 52/100), leading on trust & safety, experience, product range, reputation. TrimRx comes out ahead on value.

72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

Visit Defy Medical
52
TrimRx
Below Average

San Diego-based GLP-1 weight loss telehealth offering compounded semaglutide and tirzepatide at $179-349/month.

Visit TrimRx

Score Breakdown

DimensionDefy MedicalTrimRx
Overall Score71.9/100 ✓52/100
Trust & Safety30%72/100 ✓55/100
Value25%60/10070/100 ✓
Experience20%78/100 ✓45/100
Product Range15%78/100 ✓30/100
Reputation10%80/100 ✓45/100

At a Glance

Founded20112024
HeadquartersTampa, FLSan Diego, CA
Publicly tradedNoNo
Treatment categories31
Treatments listed46
Starting price$150/mo$179/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDefy MedicalTrimRx
Weight Loss / GLP-1$150–$250
GLP-1 Weight Loss (Semaglutide/Tirzepatide)
$179–$329
Compounded Semaglutide (Oral/Sublingual)

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

TrimRx

+70-85% savings vs brand-name GLP-1s: semaglutide at $199/mo vs $1,000+ retail
+Not included in FDA's 2025 warning letter wave — clean regulatory record
+Multiple delivery formats: injectable, oral tablet, and sublingual drops
−Cancellation difficulties: long phone waits, reports of being hung up on; dedicated JoinChargeback page exists
−Strict no-refund policy once medical intake is submitted, even before medication ships
−Very young company (founded June 2024) — less than 2 years old
Read the full TrimRx review →

Defy Medical vs TrimRx — FAQ

Is Defy Medical better than TrimRx?

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Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 52/100), leading on trust & safety, experience, product range, reputation. TrimRx comes out ahead on value.

Is Defy Medical or TrimRx cheaper?

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Defy Medical has the lower starting price (from $150/mo vs $179/mo for TrimRx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Defy Medical and TrimRx both offer?

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Both platforms treat Weight Loss / GLP-1. Defy Medical covers 3 treatment categories total and TrimRx covers 1.

Still deciding?

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