Direct Meds vs ProlongMD: Which Is Better?
Head-to-head comparison of Direct Meds and ProlongMD based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.
Our Verdict
Direct Meds scores higher overall in our independent evaluation (74.5/100 vs 60.1/100), leading on trust & safety, value, experience, product range, reputation. ProlongMD has the lower entry price (from $25/mo vs $53/mo), so the better value depends on which treatment you need.
Cash-pay pharmacy and telehealth combo focused on transparent pricing and no-surprise billing.
Visit Direct MedsSmall, veteran-owned cash-pay telehealth practice offering compounded GLP-1s, TRT, enclomiphene, women's hormones, ED, hair loss and peptides after a $79 video consult.
Visit ProlongMDScore Breakdown
| Dimension | Direct Meds | ProlongMD |
|---|---|---|
| Overall Score | 74.5/100 ✓ | 60.1/100 |
| Trust & Safety30% | 72/100 ✓ | 52/100 |
| Value25% | 82/100 ✓ | 74/100 |
| Experience20% | 74/100 ✓ | 55/100 |
| Product Range15% | 72/100 ✓ | 70/100 |
| Reputation10% | 68/100 ✓ | 45/100 |
At a Glance
| Founded | 2021 | 2025 |
| Headquarters | Miami, FL | Phoenix, AZ |
| Publicly traded | No | No |
| Treatment categories | 6 | 8 |
| Treatments listed | 9 | 13 |
| Starting price | $53/mo | $25/mo |
Pricing Where They Compete
Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.
| Category | Direct Meds | ProlongMD |
|---|---|---|
| Weight Loss / GLP-1 | $237–$249 Compounded Semaglutide (sublingual) | $99–$119 Compounded Semaglutide/B12 |
| Men's Health | — | $129–$159 Enclomiphene 25 mg |
| Sexual Health | $53–$216 DirectMax rapid-dissolve ED tablet (apomorphine + sildenafil + tadalafil) | $75 Tadalafil 24 mg |
| Longevity & Peptides | $199–$299 NAD+ Injections | $179 Sermorelin |
| Hormone Therapy | $180–$197 Women's HRT (Nuvella): estradiol, progesterone, DHEA | $89–$119 Testosterone Cypionate (200 mg/mL) |
| Women's Health | — | $33 Progesterone (oral) |
Direct Meds
ProlongMD
Direct Meds vs ProlongMD — FAQ
Is Direct Meds better than ProlongMD?
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Direct Meds scores higher overall in our independent evaluation (74.5/100 vs 60.1/100), leading on trust & safety, value, experience, product range, reputation. ProlongMD has the lower entry price (from $25/mo vs $53/mo), so the better value depends on which treatment you need.
Is Direct Meds or ProlongMD cheaper?
▾
ProlongMD has the lower starting price (from $25/mo vs $53/mo for Direct Meds). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.
What do Direct Meds and ProlongMD both offer?
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Both platforms treat Weight Loss / GLP-1, Men's Health, Sexual Health, Longevity & Peptides, Hormone Therapy, Women's Health. Direct Meds covers 6 treatment categories total and ProlongMD covers 8.
Still deciding?