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Direct Meds vs System Labs: Which Is Better?

Head-to-head comparison of Direct Meds and System Labs based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Direct Meds scores higher overall in our independent evaluation (74.5/100 vs 56.4/100), leading on trust & safety, value, experience, product range, reputation.

75

Cash-pay pharmacy and telehealth combo focused on transparent pricing and no-surprise billing.

Visit Direct Meds
56

System Labs is a San Francisco-based telehealth service prescribing compounded NAD+, sermorelin, glutathione and MIC-B12, with half-price first months.

Visit System Labs

Score Breakdown

DimensionDirect MedsSystem Labs
Overall Score74.5/100 ✓56.4/100
Trust & Safety30%72/100 ✓52/100
Value25%82/100 ✓68/100
Experience20%74/100 ✓55/100
Product Range15%72/100 ✓55/100
Reputation10%68/100 ✓45/100

At a Glance

Founded2021—
HeadquartersMiami, FLSan Francisco, CA
Publicly tradedNoNo
Treatment categories61
Treatments listed96
Starting price$53/mo$89/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDirect MedsSystem Labs
Longevity & Peptides$199–$299
NAD+ Injections
$89
MIC+B12 Injection

Direct Meds

+Transparent cash-pay pricing with no hidden fees
+Integrated pharmacy for fast fulfillment
+Competitive GLP-1 pricing
−GLP-1 tiers carry a three-month billing commitment while the same pages display a Cancel Anytime badge
−Marketing site publishes only two of sixteen-plus prices, one of them only inside invisible schema markup; the real prices sit on a storefront the marketing pages never link to
−FDA warning letter (Sept 2025, ref 716822) — compounded semaglutide and tirzepatide cited as misbranded over claims that they contain the same active ingredient as the branded drugs
Read the full Direct Meds review →

System Labs

+Every price is posted on the site, including a first-month discount of roughly 40–50%
+Names its main compounding pharmacy (The Pharmacy Hub, Miami) and three board-certified physician advisors
+Both injectable and non-injectable options (NAD+ nasal spray, oral sermorelin)
−Trustpilot removed its business profile for guideline violations, so there is no independent review base
−'20k+ patients' claim is unverified; founding date and company history are not disclosed
−All sales are final once shipped; terms impose binding arbitration and a class-action waiver
Read the full System Labs review →

Direct Meds vs System Labs — FAQ

Is Direct Meds better than System Labs?

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Direct Meds scores higher overall in our independent evaluation (74.5/100 vs 56.4/100), leading on trust & safety, value, experience, product range, reputation.

Is Direct Meds or System Labs cheaper?

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Direct Meds has the lower starting price (from $53/mo vs $89/mo for System Labs). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Direct Meds and System Labs both offer?

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Both platforms treat Longevity & Peptides. Direct Meds covers 6 treatment categories total and System Labs covers 1.

Still deciding?

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