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Direct Meds vs Twentyeight Health: Which Is Better?

Head-to-head comparison of Direct Meds and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 73.5/100), leading on trust & safety, product range, reputation. Direct Meds comes out ahead on value, experience.

74

Cash-pay pharmacy and telehealth combo focused on transparent pricing and no-surprise billing.

Visit Direct Meds
75

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health

Score Breakdown

DimensionDirect MedsTwentyeight Health
Overall Score73.5/10075/100 ✓
Trust & Safety30%72/10076/100 ✓
Value25%82/100 ✓80/100
Experience20%74/100 ✓72/100
Product Range15%65/10072/100 ✓
Reputation10%68/10070/100 ✓

At a Glance

Founded20212018
HeadquartersMiami, FLBrooklyn, NY
Publicly tradedNoNo
Treatment categories44
Treatments listed57
Starting price$199/mo$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDirect MedsTwentyeight Health
Weight Loss / GLP-1$237–$249
Compounded Semaglutide (sublingual)
—
Sexual Health——

Direct Meds

+Transparent cash-pay pricing with no hidden fees
+Integrated pharmacy for fast fulfillment
+Competitive GLP-1 pricing
−GLP-1 tiers carry a three-month billing commitment while the same pages display a Cancel Anytime badge
−Marketing site publishes only two of sixteen-plus prices, one of them only inside invisible schema markup; the real prices sit on a storefront the marketing pages never link to
−FDA warning letter (Sept 2025, ref 716822) — compounded semaglutide and tirzepatide cited as misbranded over claims that they contain the same active ingredient as the branded drugs
Read the full Direct Meds review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

Direct Meds vs Twentyeight Health — FAQ

Is Direct Meds better than Twentyeight Health?

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Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 73.5/100), leading on trust & safety, product range, reputation. Direct Meds comes out ahead on value, experience.

Is Direct Meds or Twentyeight Health cheaper?

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Twentyeight Health has the lower starting price (from $15/mo vs $199/mo for Direct Meds). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Direct Meds and Twentyeight Health both offer?

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Both platforms treat Weight Loss / GLP-1, Sexual Health. Direct Meds covers 4 treatment categories total and Twentyeight Health covers 4.

Still deciding?

Direct Meds alternativesTwentyeight Health alternativesTake the Match Quiz