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DudeMeds vs Twentyeight Health: Which Is Better?

Head-to-head comparison of DudeMeds and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 59.7/100), leading on trust & safety, value, experience, reputation. DudeMeds comes out ahead on product range.

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DudeMeds is a Florida-based men's telehealth platform built around low-cost all-inclusive TRT that has expanded into GLP-1s, ED, hair loss, NAD+ and women's HRT.

Visit DudeMeds

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health

Score Breakdown

DimensionDudeMedsTwentyeight Health
Overall Score59.7/10075/100 ✓
Trust & Safety30%55/10076/100 ✓
Value25%70/10080/100 ✓
Experience20%45/10072/100 ✓
Product Range15%78/100 ✓72/100
Reputation10%50/10070/100 ✓

At a Glance

Founded20212018
HeadquartersFloridaBrooklyn, NY
Publicly tradedNoNo
Treatment categories74
Treatments listed57
Starting price$39/mo$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDudeMedsTwentyeight Health
Sexual Health$39–$49
ED (generic sildenafil / tadalafil)
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Weight Loss / GLP-1$175–$199
Compounded Semaglutide
—
Women's Health—$15–$19.99
Complete Care Membership

DudeMeds

+All-inclusive TRT from $77/month bundles testosterone, estrogen blocker, supplies, labs and televisits, among the lowest headline TRT prices in telehealth
+Broad catalog under one account: TRT and enclomiphene, compounded and branded GLP-1s, ED, hair loss, NAD+ and LDN
+No separate membership or doctor fee on GLP-1 plans, with free shipping (per third-party pricing checks)
−Trustpilot 2.3/5 (11 reviews) with reports of unauthorized multi-month renewal charges and no company replies to negative reviews
−Patients report the member portal has been non-functional for months, plus refill delays and lost lab work
−GLP-1 pricing not published; third-party audit found the advertised $149/month entry price unavailable at checkout
Read the full DudeMeds review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

DudeMeds vs Twentyeight Health — FAQ

Is DudeMeds better than Twentyeight Health?

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Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 59.7/100), leading on trust & safety, value, experience, reputation. DudeMeds comes out ahead on product range.

Is DudeMeds or Twentyeight Health cheaper?

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Twentyeight Health has the lower starting price (from $15/mo vs $39/mo for DudeMeds). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do DudeMeds and Twentyeight Health both offer?

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Both platforms treat Sexual Health, Weight Loss / GLP-1, Women's Health. DudeMeds covers 7 treatment categories total and Twentyeight Health covers 4.

Still deciding?