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Effecty vs He & She MD: Which Is Better?

Head-to-head comparison of Effecty and He & She MD based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Effecty scores higher overall in our independent evaluation (66.8/100 vs 65.3/100), leading on trust & safety, value, experience, reputation. He & She MD comes out ahead on product range.

67

New York-based cash-pay telehealth brand selling compounded GLP-1s, longevity injectables (NAD+, sermorelin, glutathione) and estradiol HRT with no membership fee and published tiered pricing.

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65

He & She MD is a Newport Beach-based men's and women's telehealth brand covering GLP-1s, longevity injectables, HRT, testosterone, hair loss and ED, with the lowest prices tied to long prepaid terms.

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Score Breakdown

DimensionEffectyHe & She MD
Overall Score66.8/100 ✓65.3/100
Trust & Safety30%60/100 ✓58/100
Value25%76/100 ✓74/100
Experience20%72/100 ✓60/100
Product Range15%66/10084/100 ✓
Reputation10%55/100 ✓48/100

At a Glance

Founded20242025
HeadquartersNew York, NYNewport Beach, CA
Publicly tradedNoNo
Treatment categories47
Treatments listed913
Starting price$55/mo$60/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryEffectyHe & She MD
Weight Loss / GLP-1$80
Metformin
$99–$199
Compounded Semaglutide (injectable)
Longevity & Peptides$95–$150
Lipotropic (MIC) + B12
$100–$149
Glutathione
Hormone Therapy$55–$180
Estradiol (tablet, cream or patch) + Progesterone
$119
Testosterone (injection, gel, tablet)
Women's Health——

Effecty

+No membership fee, and prices are published per product and don't change with dose (semaglutide $130–$170/mo, tirzepatide $190–$235/mo)
+Card is held, not charged, until a prescription is written; shipping is free and expedited
+4.6/5 on Trustpilot across ~1,300 reviews, most citing fast support responses
−Only operating since November 2024; BBB rating is B with three closed complaints
−Visits are chat-only, and the compounding pharmacies are not named on the site
−Lowest advertised prices require 12-month prepayment; month-to-month runs 25–30% higher
Read the full Effecty review →

He & She MD

+Broad catalog covering compounded GLP-1s (injectable and oral), NAD+, sermorelin, glutathione, estradiol/progesterone HRT, testosterone, enclomiphene, hair loss and ED
+Names its dispensing pharmacies and the states where one partner cannot ship sterile compounds
+Low entry pricing on long terms: compounded semaglutide $99/mo on annual prepay, hair loss $79/mo, ED from $10/dose
−Site shows '4.8 Excellent' and 5.0 rating badges while its Trustpilot profile has zero reviews, so the ratings can't be verified
−Most headline prices require 3- to 12-month prepayment; month-to-month semaglutide is $199 and tirzepatide $299
−Platform terms allow a $15 fee per additional consult or lab-result interpretation on top of plan prices
Read the full He & She MD review →

Effecty vs He & She MD — FAQ

Is Effecty better than He & She MD?

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Effecty scores higher overall in our independent evaluation (66.8/100 vs 65.3/100), leading on trust & safety, value, experience, reputation. He & She MD comes out ahead on product range.

Is Effecty or He & She MD cheaper?

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Effecty has the lower starting price (from $55/mo vs $60/mo for He & She MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Effecty and He & She MD both offer?

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Both platforms treat Weight Loss / GLP-1, Longevity & Peptides, Hormone Therapy, Women's Health. Effecty covers 4 treatment categories total and He & She MD covers 7.

Still deciding?

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