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Effecty vs ProlongMD: Which Is Better?

Head-to-head comparison of Effecty and ProlongMD based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Effecty scores higher overall in our independent evaluation (66.8/100 vs 60.1/100), leading on trust & safety, value, experience, reputation. ProlongMD comes out ahead on product range. ProlongMD has the lower entry price (from $25/mo vs $55/mo), so the better value depends on which treatment you need.

Effecty

Good

New York-based cash-pay telehealth brand selling compounded GLP-1s, longevity injectables (NAD+, sermorelin, glutathione) and estradiol HRT with no membership fee and published tiered pricing.

Visit Effecty

ProlongMD

Fair

Small, veteran-owned cash-pay telehealth practice offering compounded GLP-1s, TRT, enclomiphene, women's hormones, ED, hair loss and peptides after a $79 video consult.

Visit ProlongMD

Score Breakdown

Dimension	Effecty	ProlongMD
Overall Score	66.8/100 ✓	60.1/100
Trust & Safety30%	60/100 ✓	52/100
Value25%	76/100 ✓	74/100
Experience20%	72/100 ✓	55/100
Product Range15%	66/100	70/100 ✓
Reputation10%	55/100 ✓	45/100

At a Glance

Founded	2024	2025
Headquarters	New York, NY	Phoenix, AZ
Publicly traded	No	No
Treatment categories	4	8
Treatments listed	9	13
Starting price	$55/mo	$25/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

Category	Effecty	ProlongMD
Weight Loss / GLP-1	$80 Metformin	$99–$119 Compounded Semaglutide/B12
Longevity & Peptides	$95–$150 Lipotropic (MIC) + B12	$179 Sermorelin
Hormone Therapy	$55–$180 Estradiol (tablet, cream or patch) + Progesterone	$89–$119 Testosterone Cypionate (200 mg/mL)
Women's Health	—	$33 Progesterone (oral)

Effecty

+No membership fee, and prices are published per product and don't change with dose (semaglutide $130–$170/mo, tirzepatide $190–$235/mo)

+Card is held, not charged, until a prescription is written; shipping is free and expedited

+4.6/5 on Trustpilot across ~1,300 reviews, most citing fast support responses

−Only operating since November 2024; BBB rating is B with three closed complaints

−Visits are chat-only, and the compounding pharmacies are not named on the site

−Lowest advertised prices require 12-month prepayment; month-to-month runs 25–30% higher

Read the full Effecty review →

ProlongMD

+Low published prices: compounded semaglutide/B12 from $99/mo and tirzepatide/B12 from $149/mo, with no membership fee

+$79 video consult is credited toward the first treatment purchase, and a written price-match policy covers comparable injectable programs

+Names its prescribing clinicians (two physicians, two nurse practitioners) and runs synchronous video visits

−Sells BPC-157/TB-500 and GHK-Cu/BPC-157/KPV/TB-500 'peptide blends', compounds the FDA has flagged for safety concerns and which have no approved drug form

−Dispensing pharmacies are not named, and the states served are not published (visible reviews come only from TX and CO)

−Very new (LLC formed August 2025) with no independent review footprint; several on-site star ratings have no review text

Read the full ProlongMD review →

Effecty vs ProlongMD — FAQ

Is Effecty better than ProlongMD?

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Is Effecty or ProlongMD cheaper?

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ProlongMD has the lower starting price (from $25/mo vs $55/mo for Effecty). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Effecty and ProlongMD both offer?

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Both platforms treat Weight Loss / GLP-1, Longevity & Peptides, Hormone Therapy, Women's Health. Effecty covers 4 treatment categories total and ProlongMD covers 8.

Still deciding?

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