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Effecty vs Twentyeight Health: Which Is Better?

Head-to-head comparison of Effecty and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 66.8/100), leading on trust & safety, value, product range, reputation.

67

New York-based cash-pay telehealth brand selling compounded GLP-1s, longevity injectables (NAD+, sermorelin, glutathione) and estradiol HRT with no membership fee and published tiered pricing.

Visit Effecty
75

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health

Score Breakdown

DimensionEffectyTwentyeight Health
Overall Score66.8/10075/100 ✓
Trust & Safety30%60/10076/100 ✓
Value25%76/10080/100 ✓
Experience20%72/10072/100
Product Range15%66/10072/100 ✓
Reputation10%55/10070/100 ✓

At a Glance

Founded20242018
HeadquartersNew York, NYBrooklyn, NY
Publicly tradedNoNo
Treatment categories44
Treatments listed97
Starting price$55/mo$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryEffectyTwentyeight Health
Weight Loss / GLP-1$80
Metformin
—
Women's Health—$15–$19.99
Complete Care Membership

Effecty

+No membership fee, and prices are published per product and don't change with dose (semaglutide $130–$170/mo, tirzepatide $190–$235/mo)
+Card is held, not charged, until a prescription is written; shipping is free and expedited
+4.6/5 on Trustpilot across ~1,300 reviews, most citing fast support responses
−Only operating since November 2024; BBB rating is B with three closed complaints
−Visits are chat-only, and the compounding pharmacies are not named on the site
−Lowest advertised prices require 12-month prepayment; month-to-month runs 25–30% higher
Read the full Effecty review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

Effecty vs Twentyeight Health — FAQ

Is Effecty better than Twentyeight Health?

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Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 66.8/100), leading on trust & safety, value, product range, reputation.

Is Effecty or Twentyeight Health cheaper?

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Twentyeight Health has the lower starting price (from $15/mo vs $55/mo for Effecty). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Effecty and Twentyeight Health both offer?

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Both platforms treat Weight Loss / GLP-1, Women's Health. Effecty covers 4 treatment categories total and Twentyeight Health covers 4.

Still deciding?

Effecty alternativesTwentyeight Health alternativesTake the Match Quiz