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He & She MD vs MangoRx: Which Is Better?

Head-to-head comparison of He & She MD and MangoRx based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

He & She MD scores higher overall in our independent evaluation (65.3/100 vs 58/100), leading on trust & safety, value, experience, product range, reputation. MangoRx has the lower entry price (from $50/mo vs $60/mo), so the better value depends on which treatment you need.

He & She MD is a Newport Beach-based men's and women's telehealth brand covering GLP-1s, longevity injectables, HRT, testosterone, hair loss and ED, with the lowest prices tied to long prepaid terms.

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MangoRx is the Dallas-based men's health telehealth brand of Nasdaq-listed Mangoceuticals, selling compounded ED, hair-loss and oral semaglutide products alongside injectable and oral (Kyzatrex) testosterone.

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Score Breakdown

DimensionHe & She MDMangoRx
Overall Score65.3/100 ✓58/100
Trust & Safety30%58/100 ✓55/100
Value25%74/100 ✓62/100
Experience20%60/100 ✓58/100
Product Range15%84/100 ✓66/100
Reputation10%48/100 ✓45/100

At a Glance

Founded20252021
HeadquartersNewport Beach, CADallas, TX
Publicly tradedNoYes (MGRX)
Treatment categories75
Treatments listed135
Starting price$60/mo$50/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryHe & She MDMangoRx
Weight Loss / GLP-1$99–$199
Compounded Semaglutide (injectable)
$299
Slim (compounded oral semaglutide ODT)
Hormone Therapy$119
Testosterone (injection, gel, tablet)
$99
Injectable TRT (testosterone cypionate)
Men's Health$139
Enclomiphene
—
Hair Loss$76–$79
Hair Growth (oral/topical/combo, men and women)
$50–$80
Grow (compounded hair-loss formula)
Sexual Health$60–$96
ED Treatment (on-demand, daily, combination)
$59–$75
Mango ED (sildenafil or tadalafil)

He & She MD

+Broad catalog covering compounded GLP-1s (injectable and oral), NAD+, sermorelin, glutathione, estradiol/progesterone HRT, testosterone, enclomiphene, hair loss and ED
+Names its dispensing pharmacies and the states where one partner cannot ship sterile compounds
+Low entry pricing on long terms: compounded semaglutide $99/mo on annual prepay, hair loss $79/mo, ED from $10/dose
−Site shows '4.8 Excellent' and 5.0 rating badges while its Trustpilot profile has zero reviews, so the ratings can't be verified
−Most headline prices require 3- to 12-month prepayment; month-to-month semaglutide is $199 and tirzepatide $299
−Platform terms allow a $15 fee per additional consult or lab-result interpretation on top of plan prices
Read the full He & She MD review →

MangoRx

+Injectable TRT program priced at $99/month with doctor visits, lab work and medication included (per February 2026 company release and current site listing)
+Offers a branded FDA-approved oral testosterone option (Kyzatrex-based 'Prime') alongside compounded injectable TRT, which few small men's-health platforms carry
+Public-company SEC disclosures make ownership, pharmacy relationships and finances unusually visible for a brand this size
−Going-concern risk: $228,688 cash on hand at June 30, 2026 against a six-month net loss of $4.7M, per its Q2 2026 10-Q
−Compounded products are filled by Epiq Scripts, a pharmacy majority-owned (52%) by the CEO, a related-party arrangement
−Very small patient base: Q2 2026 revenue of $68,757, down 59% year over year, and only 18 Trustpilot reviews
Read the full MangoRx review →

He & She MD vs MangoRx — FAQ

Is He & She MD better than MangoRx?

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He & She MD scores higher overall in our independent evaluation (65.3/100 vs 58/100), leading on trust & safety, value, experience, product range, reputation. MangoRx has the lower entry price (from $50/mo vs $60/mo), so the better value depends on which treatment you need.

Is He & She MD or MangoRx cheaper?

▾

MangoRx has the lower starting price (from $50/mo vs $60/mo for He & She MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do He & She MD and MangoRx both offer?

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Both platforms treat Weight Loss / GLP-1, Hormone Therapy, Men's Health, Hair Loss, Sexual Health. He & She MD covers 7 treatment categories total and MangoRx covers 5.

Still deciding?