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He & She MD vs PlushCare: Which Is Better?

Head-to-head comparison of He & She MD and PlushCare based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

PlushCare scores higher overall in our independent evaluation (68.3/100 vs 65.3/100), leading on trust & safety, experience, reputation. He & She MD comes out ahead on value, product range.

65

He & She MD is a Newport Beach-based men's and women's telehealth brand covering GLP-1s, longevity injectables, HRT, testosterone, hair loss and ED, with the lowest prices tied to long prepaid terms.

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68

PlushCare is a virtual primary-care membership service that layers weight-loss visits and branded GLP-1 prescriptions onto its core telehealth offering, rather than running a dedicated compounded-GLP-1 program.

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Score Breakdown

DimensionHe & She MDPlushCare
Overall Score65.3/10068.3/100 ✓
Trust & Safety30%58/10078/100 ✓
Value25%74/100 ✓62/100
Experience20%60/10062/100 ✓
Product Range15%84/100 ✓65/100
Reputation10%48/10072/100 ✓

At a Glance

Founded20252014
HeadquartersNewport Beach, CASan Francisco, CA
Publicly tradedNoNo
Treatment categories72
Treatments listed133
Starting price$60/mo$20/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryHe & She MDPlushCare
Weight Loss / GLP-1$99–$199
Compounded Semaglutide (injectable)
$650–$1100
Branded GLP-1 Prescription (Wegovy, Saxenda)

He & She MD

+Broad catalog covering compounded GLP-1s (injectable and oral), NAD+, sermorelin, glutathione, estradiol/progesterone HRT, testosterone, enclomiphene, hair loss and ED
+Names its dispensing pharmacies and the states where one partner cannot ship sterile compounds
+Low entry pricing on long terms: compounded semaglutide $99/mo on annual prepay, hair loss $79/mo, ED from $10/dose
−Site shows '4.8 Excellent' and 5.0 rating badges while its Trustpilot profile has zero reviews, so the ratings can't be verified
−Most headline prices require 3- to 12-month prepayment; month-to-month semaglutide is $199 and tirzepatide $299
−Platform terms allow a $15 fee per additional consult or lab-result interpretation on top of plan prices
Read the full He & She MD review →

PlushCare

+Low $19.99/mo membership with first month free, and insurance-eligible visits as low as a $30 copay
+Accepts major insurance plans (Aetna, Cigna, Humana), broader than most single-purpose GLP-1 telehealth startups
+Physician-led primary care model covers ongoing and chronic care beyond a single weight-loss funnel
−Branded GLP-1 medication (Zepbound, Wegovy) is billed separately at the pharmacy — without insurance coverage this can run roughly $1,000+/month, dwarfing the low membership fee
−No compounded GLP-1 option, so cash-pay patients without drug coverage face full retail brand pricing
−Trustpilot pattern of unexpected recurring membership charges and difficulty cancelling
Read the full PlushCare review →

He & She MD vs PlushCare — FAQ

Is He & She MD better than PlushCare?

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PlushCare scores higher overall in our independent evaluation (68.3/100 vs 65.3/100), leading on trust & safety, experience, reputation. He & She MD comes out ahead on value, product range.

Is He & She MD or PlushCare cheaper?

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PlushCare has the lower starting price (from $20/mo vs $60/mo for He & She MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do He & She MD and PlushCare both offer?

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Both platforms treat Weight Loss / GLP-1. He & She MD covers 7 treatment categories total and PlushCare covers 2.

Still deciding?

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