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He & She MD vs RxSpan MD: Which Is Better?

Head-to-head comparison of He & She MD and RxSpan MD based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

He & She MD scores higher overall in our independent evaluation (65.3/100 vs 59.1/100), leading on value, experience, product range, reputation. RxSpan MD comes out ahead on trust & safety. RxSpan MD has the lower entry price (from $30/mo vs $60/mo), so the better value depends on which treatment you need.

He & She MD is a Newport Beach-based men's and women's telehealth brand covering GLP-1s, longevity injectables, HRT, testosterone, hair loss and ED, with the lowest prices tied to long prepaid terms.

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RxSpan MD is a Beverly Hills telehealth practice founded by a plastic surgeon, offering compounded and branded GLP-1s, longevity peptides, hair-loss and ED treatment.

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Score Breakdown

DimensionHe & She MDRxSpan MD
Overall Score65.3/100 ✓59.1/100
Trust & Safety30%58/10060/100 ✓
Value25%74/100 ✓58/100
Experience20%60/100 ✓52/100
Product Range15%84/100 ✓78/100
Reputation10%48/100 ✓45/100

At a Glance

Founded20252026
HeadquartersNewport Beach, CABeverly Hills, CA
Publicly tradedNoNo
Treatment categories74
Treatments listed139
Starting price$60/mo$30/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryHe & She MDRxSpan MD
Weight Loss / GLP-1$99–$199
Compounded Semaglutide (injectable)
$249–$299
Compounded Semaglutide (injection or oral)
Longevity & Peptides$100–$149
Glutathione
$100–$200
Glutathione
Hair Loss$76–$79
Hair Growth (oral/topical/combo, men and women)
$30–$80
Hair Loss (oral minoxidil, finasteride/minoxidil, dutasteride)
Sexual Health$60–$96
ED Treatment (on-demand, daily, combination)
$30–$100
ED (tadalafil, sildenafil/pycnogenol, vardenafil)

He & She MD

+Broad catalog covering compounded GLP-1s (injectable and oral), NAD+, sermorelin, glutathione, estradiol/progesterone HRT, testosterone, enclomiphene, hair loss and ED
+Names its dispensing pharmacies and the states where one partner cannot ship sterile compounds
+Low entry pricing on long terms: compounded semaglutide $99/mo on annual prepay, hair loss $79/mo, ED from $10/dose
−Site shows '4.8 Excellent' and 5.0 rating badges while its Trustpilot profile has zero reviews, so the ratings can't be verified
−Most headline prices require 3- to 12-month prepayment; month-to-month semaglutide is $199 and tirzepatide $299
−Platform terms allow a $15 fee per additional consult or lab-result interpretation on top of plan prices
Read the full He & She MD review →

RxSpan MD

+Physician-founded practice with a named founder and a stated Beverly Hills address
+Offers both compounded (injection and oral) and branded GLP-1s, including cash-pay Zepbound listed at $500
+Third-party coverage reports named 503A pharmacy partners and free expedited shipping
−Compounded prices aren't visible on the public site; its product catalog failed to load during our research
−Brand-stated first-month prices ($249 semaglutide, $329 tirzepatide) are above peer averages, and renewal pricing is not published
−Site configuration shows an $80 initial visit fee that is not prominently disclosed
Read the full RxSpan MD review →

He & She MD vs RxSpan MD — FAQ

Is He & She MD better than RxSpan MD?

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He & She MD scores higher overall in our independent evaluation (65.3/100 vs 59.1/100), leading on value, experience, product range, reputation. RxSpan MD comes out ahead on trust & safety. RxSpan MD has the lower entry price (from $30/mo vs $60/mo), so the better value depends on which treatment you need.

Is He & She MD or RxSpan MD cheaper?

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RxSpan MD has the lower starting price (from $30/mo vs $60/mo for He & She MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do He & She MD and RxSpan MD both offer?

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Both platforms treat Weight Loss / GLP-1, Longevity & Peptides, Hair Loss, Sexual Health. He & She MD covers 7 treatment categories total and RxSpan MD covers 4.

Still deciding?