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He & She MD vs Sesame Care: Which Is Better?

Head-to-head comparison of He & She MD and Sesame Care based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Sesame Care scores higher overall in our independent evaluation (74/100 vs 65.3/100), leading on trust & safety, value, experience, reputation. He & She MD comes out ahead on product range.

He & She MD is a Newport Beach-based men's and women's telehealth brand covering GLP-1s, longevity injectables, HRT, testosterone, hair loss and ED, with the lowest prices tied to long prepaid terms.

Visit He & She MD

Pay-per-visit marketplace connecting patients with licensed providers — no subscriptions, transparent per-visit pricing.

Visit Sesame Care

Score Breakdown

DimensionHe & She MDSesame Care
Overall Score65.3/10074/100 ✓
Trust & Safety30%58/10075/100 ✓
Value25%74/10080/100 ✓
Experience20%60/10070/100 ✓
Product Range15%84/100 ✓70/100
Reputation10%48/10070/100 ✓

At a Glance

Founded20252019
HeadquartersNewport Beach, CANew York, NY
Publicly tradedNoNo
Treatment categories76
Treatments listed137
Starting price$60/mo$11/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryHe & She MDSesame Care
Weight Loss / GLP-1$99–$199
Compounded Semaglutide (injectable)
$59–$99
Weight Loss Program (subscription)
Women's Health——
Men's Health$139
Enclomiphene
—

He & She MD

+Broad catalog covering compounded GLP-1s (injectable and oral), NAD+, sermorelin, glutathione, estradiol/progesterone HRT, testosterone, enclomiphene, hair loss and ED
+Names its dispensing pharmacies and the states where one partner cannot ship sterile compounds
+Low entry pricing on long terms: compounded semaglutide $99/mo on annual prepay, hair loss $79/mo, ED from $10/dose
−Site shows '4.8 Excellent' and 5.0 rating badges while its Trustpilot profile has zero reviews, so the ratings can't be verified
−Most headline prices require 3- to 12-month prepayment; month-to-month semaglutide is $199 and tirzepatide $299
−Platform terms allow a $15 fee per additional consult or lab-result interpretation on top of plan prices
Read the full He & She MD review →

Sesame Care

+No subscription required — pay-per-visit model
+Transparent pricing shown before booking
+Wide range of specialties available
−No integrated pharmacy
−Less continuity of care than subscriptions
−Provider quality varies in marketplace model
Read the full Sesame Care review →

He & She MD vs Sesame Care — FAQ

Is He & She MD better than Sesame Care?

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Sesame Care scores higher overall in our independent evaluation (74/100 vs 65.3/100), leading on trust & safety, value, experience, reputation. He & She MD comes out ahead on product range.

Is He & She MD or Sesame Care cheaper?

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Sesame Care has the lower starting price (from $11/mo vs $60/mo for He & She MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do He & She MD and Sesame Care both offer?

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Both platforms treat Weight Loss / GLP-1, Women's Health, Men's Health. He & She MD covers 7 treatment categories total and Sesame Care covers 6.

Still deciding?