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He & She MD vs System Labs: Which Is Better?

Head-to-head comparison of He & She MD and System Labs based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

He & She MD scores higher overall in our independent evaluation (65.3/100 vs 56.4/100), leading on trust & safety, value, experience, product range, reputation.

65

He & She MD is a Newport Beach-based men's and women's telehealth brand covering GLP-1s, longevity injectables, HRT, testosterone, hair loss and ED, with the lowest prices tied to long prepaid terms.

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56

System Labs is a San Francisco-based telehealth service prescribing compounded NAD+, sermorelin, glutathione and MIC-B12, with half-price first months.

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Score Breakdown

DimensionHe & She MDSystem Labs
Overall Score65.3/100 ✓56.4/100
Trust & Safety30%58/100 ✓52/100
Value25%74/100 ✓68/100
Experience20%60/100 ✓55/100
Product Range15%84/100 ✓55/100
Reputation10%48/100 ✓45/100

At a Glance

Founded2025—
HeadquartersNewport Beach, CASan Francisco, CA
Publicly tradedNoNo
Treatment categories71
Treatments listed136
Starting price$60/mo$89/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryHe & She MDSystem Labs
Longevity & Peptides$100–$149
Glutathione
$89
MIC+B12 Injection

He & She MD

+Broad catalog covering compounded GLP-1s (injectable and oral), NAD+, sermorelin, glutathione, estradiol/progesterone HRT, testosterone, enclomiphene, hair loss and ED
+Names its dispensing pharmacies and the states where one partner cannot ship sterile compounds
+Low entry pricing on long terms: compounded semaglutide $99/mo on annual prepay, hair loss $79/mo, ED from $10/dose
−Site shows '4.8 Excellent' and 5.0 rating badges while its Trustpilot profile has zero reviews, so the ratings can't be verified
−Most headline prices require 3- to 12-month prepayment; month-to-month semaglutide is $199 and tirzepatide $299
−Platform terms allow a $15 fee per additional consult or lab-result interpretation on top of plan prices
Read the full He & She MD review →

System Labs

+Every price is posted on the site, including a first-month discount of roughly 40–50%
+Names its main compounding pharmacy (The Pharmacy Hub, Miami) and three board-certified physician advisors
+Both injectable and non-injectable options (NAD+ nasal spray, oral sermorelin)
−Trustpilot removed its business profile for guideline violations, so there is no independent review base
−'20k+ patients' claim is unverified; founding date and company history are not disclosed
−All sales are final once shipped; terms impose binding arbitration and a class-action waiver
Read the full System Labs review →

He & She MD vs System Labs — FAQ

Is He & She MD better than System Labs?

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He & She MD scores higher overall in our independent evaluation (65.3/100 vs 56.4/100), leading on trust & safety, value, experience, product range, reputation.

Is He & She MD or System Labs cheaper?

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He & She MD has the lower starting price (from $60/mo vs $89/mo for System Labs). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do He & She MD and System Labs both offer?

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Both platforms treat Longevity & Peptides. He & She MD covers 7 treatment categories total and System Labs covers 1.

Still deciding?

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