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HealthRX vs Twentyeight Health: Which Is Better?

Head-to-head comparison of HealthRX and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 59.3/100), leading on trust & safety, value, experience, product range, reputation.

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HealthRX.com is a compounded-GLP-1 telehealth marketplace. It sells semaglutide at $165/mo and tirzepatide at $214/mo at every dose, and backs its program with a weight-loss money-back guarantee.

Visit HealthRX
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Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health

Score Breakdown

DimensionHealthRXTwentyeight Health
Overall Score59.3/10075/100 ✓
Trust & Safety30%55/10076/100 ✓
Value25%78/10080/100 ✓
Experience20%60/10072/100 ✓
Product Range15%45/10072/100 ✓
Reputation10%45/10070/100 ✓

At a Glance

Founded20232018
Headquarters—Brooklyn, NY
Publicly tradedNoNo
Treatment categories14
Treatments listed27
Starting price$99/mo$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryHealthRXTwentyeight Health
Weight Loss / GLP-1$99–$165
Compounded Semaglutide
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HealthRX

+Flat pricing at every dose: semaglutide $165/mo ($149 first month) and tirzepatide $214/mo ($193 first month); about $99/mo semaglutide on a 12-month plan
+Physician review within 24 hours, overnight cold-chain shipping included, and a full refund if not prescribed
+Weight-loss money-back guarantee (reported terms: 16+ weeks on treatment, 10% loss threshold)
−Operating company, headquarters, medical group and dispensing pharmacy are not named; terms reference only a San Diego dispute venue
−Guarantee measurement and refund mechanics are not fully published
−Thin independent review footprint for a brand active since about 2023
Read the full HealthRX review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

HealthRX vs Twentyeight Health — FAQ

Is HealthRX better than Twentyeight Health?

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Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 59.3/100), leading on trust & safety, value, experience, product range, reputation.

Is HealthRX or Twentyeight Health cheaper?

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Twentyeight Health has the lower starting price (from $15/mo vs $99/mo for HealthRX). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do HealthRX and Twentyeight Health both offer?

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Both platforms treat Weight Loss / GLP-1. HealthRX covers 1 treatment category total and Twentyeight Health covers 4.

Still deciding?

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