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LifeMD vs Twentyeight Health: Which Is Better?

Head-to-head comparison of LifeMD and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 68/100), leading on trust & safety, value, experience, product range, reputation. LifeMD has the lower entry price (from $14/mo vs $15/mo), so the better value depends on which treatment you need.

68
LifeMD
Good

Publicly traded telehealth betting big on weight loss, with aggressive GLP-1 pricing and fast-growing subscriber base.

Visit LifeMD
75

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health

Score Breakdown

DimensionLifeMDTwentyeight Health
Overall Score68/10075/100 ✓
Trust & Safety30%65/10076/100 ✓
Value25%75/10080/100 ✓
Experience20%70/10072/100 ✓
Product Range15%65/10072/100 ✓
Reputation10%60/10070/100 ✓

At a Glance

Founded20202018
HeadquartersNew York, NYBrooklyn, NY
Publicly tradedYes (LFMD)No
Treatment categories64
Treatments listed57
Starting price$14/mo$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryLifeMDTwentyeight Health
Weight Loss / GLP-1$149–$349
Branded Wegovy (oral/injectable)
—
Sexual Health$14–$38
Sildenafil (via Rex MD)
—
Dermatology——

LifeMD

+Novo Nordisk partnership for branded Wegovy pill and subscription program
+Eli Lilly partnership for branded Zepbound access
+Publicly traded with quarterly earnings transparency — 25% revenue growth in 2025
−Compounded GLP-1s discontinued — pivoted to branded medications
−Aggressive marketing draws scrutiny from health professionals
−Narrower treatment range than Hims or Ro
Read the full LifeMD review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

LifeMD vs Twentyeight Health — FAQ

Is LifeMD better than Twentyeight Health?

▾

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 68/100), leading on trust & safety, value, experience, product range, reputation. LifeMD has the lower entry price (from $14/mo vs $15/mo), so the better value depends on which treatment you need.

Is LifeMD or Twentyeight Health cheaper?

▾

LifeMD has the lower starting price (from $14/mo vs $15/mo for Twentyeight Health). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do LifeMD and Twentyeight Health both offer?

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Both platforms treat Weight Loss / GLP-1, Sexual Health, Dermatology. LifeMD covers 6 treatment categories total and Twentyeight Health covers 4.

Still deciding?

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