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MadeMed vs Twentyeight Health: Which Is Better?

Head-to-head comparison of MadeMed and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 57.3/100), leading on trust & safety, value, experience, reputation.

57

MadeMed is a Houston-registered telehealth brand selling compounded injectable and oral GLP-1s, sermorelin, NAD+ and tadalafil through the Xpedicare provider network.

Visit MadeMed
75

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health

Score Breakdown

DimensionMadeMedTwentyeight Health
Overall Score57.3/10075/100 ✓
Trust & Safety30%55/10076/100 ✓
Value25%66/10080/100 ✓
Experience20%45/10072/100 ✓
Product Range15%72/10072/100
Reputation10%45/10070/100 ✓

At a Glance

Founded—2018
HeadquartersHouston, TXBrooklyn, NY
Publicly tradedNoNo
Treatment categories34
Treatments listed77
Starting price$30/mo$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryMadeMedTwentyeight Health
Weight Loss / GLP-1$99–$199
Compounded Semaglutide (injectable)
—
Sexual Health$30–$90
Tadalafil
—

MadeMed

+Offers both injectable and oral/sublingual versions of semaglutide, tirzepatide and sermorelin, plus NAD+ as injection or nasal spray
+Operating entity, provider network (Xpedicare) and a partner pharmacy (Red Rock) are named in the terms and About page
+Advertised GLP-1 entry pricing from $99/mo is at the low end of the market
−Product pages showed no pricing or product detail during our research, in a direct fetch or a real browser
−Advertised prices and state coverage (about 40 states) come from brand-issued press releases and can't be verified on-site
−No Trustpilot or other independent patient reviews; public coverage is mostly paid newswire content
Read the full MadeMed review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

MadeMed vs Twentyeight Health — FAQ

Is MadeMed better than Twentyeight Health?

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Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 57.3/100), leading on trust & safety, value, experience, reputation.

Is MadeMed or Twentyeight Health cheaper?

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Twentyeight Health has the lower starting price (from $15/mo vs $30/mo for MadeMed). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do MadeMed and Twentyeight Health both offer?

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Both platforms treat Weight Loss / GLP-1, Sexual Health. MadeMed covers 3 treatment categories total and Twentyeight Health covers 4.

Still deciding?

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