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PlushCare vs RxSpan MD: Which Is Better?

Head-to-head comparison of PlushCare and RxSpan MD based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

PlushCare scores higher overall in our independent evaluation (68.3/100 vs 59.1/100), leading on trust & safety, value, experience, reputation. RxSpan MD comes out ahead on product range.

68

PlushCare is a virtual primary-care membership service that layers weight-loss visits and branded GLP-1 prescriptions onto its core telehealth offering, rather than running a dedicated compounded-GLP-1 program.

Visit PlushCare
59

RxSpan MD is a Beverly Hills telehealth practice founded by a plastic surgeon, offering compounded and branded GLP-1s, longevity peptides, hair-loss and ED treatment.

Visit RxSpan MD

Score Breakdown

DimensionPlushCareRxSpan MD
Overall Score68.3/100 ✓59.1/100
Trust & Safety30%78/100 ✓60/100
Value25%62/100 ✓58/100
Experience20%62/100 ✓52/100
Product Range15%65/10078/100 ✓
Reputation10%72/100 ✓45/100

At a Glance

Founded20142026
HeadquartersSan Francisco, CABeverly Hills, CA
Publicly tradedNoNo
Treatment categories24
Treatments listed39
Starting price$20/mo$30/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryPlushCareRxSpan MD
Weight Loss / GLP-1$650–$1100
Branded GLP-1 Prescription (Wegovy, Saxenda)
$249–$299
Compounded Semaglutide (injection or oral)

PlushCare

+Low $19.99/mo membership with first month free, and insurance-eligible visits as low as a $30 copay
+Accepts major insurance plans (Aetna, Cigna, Humana), broader than most single-purpose GLP-1 telehealth startups
+Physician-led primary care model covers ongoing and chronic care beyond a single weight-loss funnel
−Branded GLP-1 medication (Zepbound, Wegovy) is billed separately at the pharmacy — without insurance coverage this can run roughly $1,000+/month, dwarfing the low membership fee
−No compounded GLP-1 option, so cash-pay patients without drug coverage face full retail brand pricing
−Trustpilot pattern of unexpected recurring membership charges and difficulty cancelling
Read the full PlushCare review →

RxSpan MD

+Physician-founded practice with a named founder and a stated Beverly Hills address
+Offers both compounded (injection and oral) and branded GLP-1s, including cash-pay Zepbound listed at $500
+Third-party coverage reports named 503A pharmacy partners and free expedited shipping
−Compounded prices aren't visible on the public site; its product catalog failed to load during our research
−Brand-stated first-month prices ($249 semaglutide, $329 tirzepatide) are above peer averages, and renewal pricing is not published
−Site configuration shows an $80 initial visit fee that is not prominently disclosed
Read the full RxSpan MD review →

PlushCare vs RxSpan MD — FAQ

Is PlushCare better than RxSpan MD?

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PlushCare scores higher overall in our independent evaluation (68.3/100 vs 59.1/100), leading on trust & safety, value, experience, reputation. RxSpan MD comes out ahead on product range.

Is PlushCare or RxSpan MD cheaper?

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PlushCare has the lower starting price (from $20/mo vs $30/mo for RxSpan MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do PlushCare and RxSpan MD both offer?

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Both platforms treat Weight Loss / GLP-1. PlushCare covers 2 treatment categories total and RxSpan MD covers 4.

Still deciding?

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