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PlushCare vs Twentyeight Health: Which Is Better?

Head-to-head comparison of PlushCare and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 68.3/100), leading on value, experience, product range. PlushCare comes out ahead on trust & safety, reputation.

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PlushCare is a virtual primary-care membership service that layers weight-loss visits and branded GLP-1 prescriptions onto its core telehealth offering, rather than running a dedicated compounded-GLP-1 program.

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Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

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Score Breakdown

DimensionPlushCareTwentyeight Health
Overall Score68.3/10075/100 ✓
Trust & Safety30%78/100 ✓76/100
Value25%62/10080/100 ✓
Experience20%62/10072/100 ✓
Product Range15%65/10072/100 ✓
Reputation10%72/100 ✓70/100

At a Glance

Founded20142018
HeadquartersSan Francisco, CABrooklyn, NY
Publicly tradedNoNo
Treatment categories24
Treatments listed37
Starting price$20/mo$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryPlushCareTwentyeight Health
Weight Loss / GLP-1$650–$1100
Branded GLP-1 Prescription (Wegovy, Saxenda)
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PlushCare

+Low $19.99/mo membership with first month free, and insurance-eligible visits as low as a $30 copay
+Accepts major insurance plans (Aetna, Cigna, Humana), broader than most single-purpose GLP-1 telehealth startups
+Physician-led primary care model covers ongoing and chronic care beyond a single weight-loss funnel
−Branded GLP-1 medication (Zepbound, Wegovy) is billed separately at the pharmacy — without insurance coverage this can run roughly $1,000+/month, dwarfing the low membership fee
−No compounded GLP-1 option, so cash-pay patients without drug coverage face full retail brand pricing
−Trustpilot pattern of unexpected recurring membership charges and difficulty cancelling
Read the full PlushCare review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

PlushCare vs Twentyeight Health — FAQ

Is PlushCare better than Twentyeight Health?

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Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 68.3/100), leading on value, experience, product range. PlushCare comes out ahead on trust & safety, reputation.

Is PlushCare or Twentyeight Health cheaper?

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Twentyeight Health has the lower starting price (from $15/mo vs $20/mo for PlushCare). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do PlushCare and Twentyeight Health both offer?

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Both platforms treat Weight Loss / GLP-1. PlushCare covers 2 treatment categories total and Twentyeight Health covers 4.

Still deciding?

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