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ProlongMD vs RxSpan MD: Which Is Better?

Head-to-head comparison of ProlongMD and RxSpan MD based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

ProlongMD scores higher overall in our independent evaluation (60.1/100 vs 59.1/100), leading on value, experience. RxSpan MD comes out ahead on trust & safety, product range.

60

Small, veteran-owned cash-pay telehealth practice offering compounded GLP-1s, TRT, enclomiphene, women's hormones, ED, hair loss and peptides after a $79 video consult.

Visit ProlongMD
59

RxSpan MD is a Beverly Hills telehealth practice founded by a plastic surgeon, offering compounded and branded GLP-1s, longevity peptides, hair-loss and ED treatment.

Visit RxSpan MD

Score Breakdown

DimensionProlongMDRxSpan MD
Overall Score60.1/100 ✓59.1/100
Trust & Safety30%52/10060/100 ✓
Value25%74/100 ✓58/100
Experience20%55/100 ✓52/100
Product Range15%70/10078/100 ✓
Reputation10%45/10045/100

At a Glance

Founded20252026
HeadquartersPhoenix, AZBeverly Hills, CA
Publicly tradedNoNo
Treatment categories84
Treatments listed139
Starting price$25/mo$30/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryProlongMDRxSpan MD
Weight Loss / GLP-1$99–$119
Compounded Semaglutide/B12
$249–$299
Compounded Semaglutide (injection or oral)
Sexual Health$75
Tadalafil 24 mg
$30–$100
ED (tadalafil, sildenafil/pycnogenol, vardenafil)
Hair Loss$25
Oral Finasteride 5 mg
$30–$80
Hair Loss (oral minoxidil, finasteride/minoxidil, dutasteride)
Longevity & Peptides$179
Sermorelin
$100–$200
Glutathione

ProlongMD

+Low published prices: compounded semaglutide/B12 from $99/mo and tirzepatide/B12 from $149/mo, with no membership fee
+$79 video consult is credited toward the first treatment purchase, and a written price-match policy covers comparable injectable programs
+Names its prescribing clinicians (two physicians, two nurse practitioners) and runs synchronous video visits
−Sells BPC-157/TB-500 and GHK-Cu/BPC-157/KPV/TB-500 'peptide blends', compounds the FDA has flagged for safety concerns and which have no approved drug form
−Dispensing pharmacies are not named, and the states served are not published (visible reviews come only from TX and CO)
−Very new (LLC formed August 2025) with no independent review footprint; several on-site star ratings have no review text
Read the full ProlongMD review →

RxSpan MD

+Physician-founded practice with a named founder and a stated Beverly Hills address
+Offers both compounded (injection and oral) and branded GLP-1s, including cash-pay Zepbound listed at $500
+Third-party coverage reports named 503A pharmacy partners and free expedited shipping
−Compounded prices aren't visible on the public site; its product catalog failed to load during our research
−Brand-stated first-month prices ($249 semaglutide, $329 tirzepatide) are above peer averages, and renewal pricing is not published
−Site configuration shows an $80 initial visit fee that is not prominently disclosed
Read the full RxSpan MD review →

ProlongMD vs RxSpan MD — FAQ

Is ProlongMD better than RxSpan MD?

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ProlongMD scores higher overall in our independent evaluation (60.1/100 vs 59.1/100), leading on value, experience. RxSpan MD comes out ahead on trust & safety, product range.

Is ProlongMD or RxSpan MD cheaper?

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ProlongMD has the lower starting price (from $25/mo vs $30/mo for RxSpan MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do ProlongMD and RxSpan MD both offer?

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Both platforms treat Weight Loss / GLP-1, Sexual Health, Hair Loss, Longevity & Peptides. ProlongMD covers 8 treatment categories total and RxSpan MD covers 4.

Still deciding?