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ProlongMD vs Sesame Care: Which Is Better?

Head-to-head comparison of ProlongMD and Sesame Care based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Sesame Care scores higher overall in our independent evaluation (74/100 vs 60.1/100), leading on trust & safety, value, experience, reputation.

60

Small, veteran-owned cash-pay telehealth practice offering compounded GLP-1s, TRT, enclomiphene, women's hormones, ED, hair loss and peptides after a $79 video consult.

Visit ProlongMD
74

Pay-per-visit marketplace connecting patients with licensed providers — no subscriptions, transparent per-visit pricing.

Visit Sesame Care

Score Breakdown

DimensionProlongMDSesame Care
Overall Score60.1/10074/100 ✓
Trust & Safety30%52/10075/100 ✓
Value25%74/10080/100 ✓
Experience20%55/10070/100 ✓
Product Range15%70/10070/100
Reputation10%45/10070/100 ✓

At a Glance

Founded20252019
HeadquartersPhoenix, AZNew York, NY
Publicly tradedNoNo
Treatment categories86
Treatments listed137
Starting price$25/mo$11/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryProlongMDSesame Care
Weight Loss / GLP-1$99–$119
Compounded Semaglutide/B12
$59–$99
Weight Loss Program (subscription)
Men's Health$129–$159
Enclomiphene 25 mg
—
Women's Health$33
Progesterone (oral)
—
Primary Care$79
Consultation (30-min video, credited toward treatment)
$11
Sesame Plus membership

ProlongMD

+Low published prices: compounded semaglutide/B12 from $99/mo and tirzepatide/B12 from $149/mo, with no membership fee
+$79 video consult is credited toward the first treatment purchase, and a written price-match policy covers comparable injectable programs
+Names its prescribing clinicians (two physicians, two nurse practitioners) and runs synchronous video visits
−Sells BPC-157/TB-500 and GHK-Cu/BPC-157/KPV/TB-500 'peptide blends', compounds the FDA has flagged for safety concerns and which have no approved drug form
−Dispensing pharmacies are not named, and the states served are not published (visible reviews come only from TX and CO)
−Very new (LLC formed August 2025) with no independent review footprint; several on-site star ratings have no review text
Read the full ProlongMD review →

Sesame Care

+No subscription required — pay-per-visit model
+Transparent pricing shown before booking
+Wide range of specialties available
−No integrated pharmacy
−Less continuity of care than subscriptions
−Provider quality varies in marketplace model
Read the full Sesame Care review →

ProlongMD vs Sesame Care — FAQ

Is ProlongMD better than Sesame Care?

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Sesame Care scores higher overall in our independent evaluation (74/100 vs 60.1/100), leading on trust & safety, value, experience, reputation.

Is ProlongMD or Sesame Care cheaper?

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Sesame Care has the lower starting price (from $11/mo vs $25/mo for ProlongMD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do ProlongMD and Sesame Care both offer?

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Both platforms treat Weight Loss / GLP-1, Men's Health, Women's Health, Primary Care. ProlongMD covers 8 treatment categories total and Sesame Care covers 6.

Still deciding?

ProlongMD alternativesSesame Care alternativesTake the Match Quiz