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ProlongMD vs System Labs: Which Is Better?

Head-to-head comparison of ProlongMD and System Labs based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

ProlongMD scores higher overall in our independent evaluation (60.1/100 vs 56.4/100), leading on value, product range.

60

Small, veteran-owned cash-pay telehealth practice offering compounded GLP-1s, TRT, enclomiphene, women's hormones, ED, hair loss and peptides after a $79 video consult.

Visit ProlongMD
56

System Labs is a San Francisco-based telehealth service prescribing compounded NAD+, sermorelin, glutathione and MIC-B12, with half-price first months.

Visit System Labs

Score Breakdown

DimensionProlongMDSystem Labs
Overall Score60.1/100 ✓56.4/100
Trust & Safety30%52/10052/100
Value25%74/100 ✓68/100
Experience20%55/10055/100
Product Range15%70/100 ✓55/100
Reputation10%45/10045/100

At a Glance

Founded2025—
HeadquartersPhoenix, AZSan Francisco, CA
Publicly tradedNoNo
Treatment categories81
Treatments listed136
Starting price$25/mo$89/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryProlongMDSystem Labs
Longevity & Peptides$179
Sermorelin
$89
MIC+B12 Injection

ProlongMD

+Low published prices: compounded semaglutide/B12 from $99/mo and tirzepatide/B12 from $149/mo, with no membership fee
+$79 video consult is credited toward the first treatment purchase, and a written price-match policy covers comparable injectable programs
+Names its prescribing clinicians (two physicians, two nurse practitioners) and runs synchronous video visits
−Sells BPC-157/TB-500 and GHK-Cu/BPC-157/KPV/TB-500 'peptide blends', compounds the FDA has flagged for safety concerns and which have no approved drug form
−Dispensing pharmacies are not named, and the states served are not published (visible reviews come only from TX and CO)
−Very new (LLC formed August 2025) with no independent review footprint; several on-site star ratings have no review text
Read the full ProlongMD review →

System Labs

+Every price is posted on the site, including a first-month discount of roughly 40–50%
+Names its main compounding pharmacy (The Pharmacy Hub, Miami) and three board-certified physician advisors
+Both injectable and non-injectable options (NAD+ nasal spray, oral sermorelin)
−Trustpilot removed its business profile for guideline violations, so there is no independent review base
−'20k+ patients' claim is unverified; founding date and company history are not disclosed
−All sales are final once shipped; terms impose binding arbitration and a class-action waiver
Read the full System Labs review →

ProlongMD vs System Labs — FAQ

Is ProlongMD better than System Labs?

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ProlongMD scores higher overall in our independent evaluation (60.1/100 vs 56.4/100), leading on value, product range.

Is ProlongMD or System Labs cheaper?

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ProlongMD has the lower starting price (from $25/mo vs $89/mo for System Labs). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do ProlongMD and System Labs both offer?

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Both platforms treat Longevity & Peptides. ProlongMD covers 8 treatment categories total and System Labs covers 1.

Still deciding?

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