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ProlongMD vs Twentyeight Health: Which Is Better?

Head-to-head comparison of ProlongMD and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 60.1/100), leading on trust & safety, value, experience, product range, reputation.

60

Small, veteran-owned cash-pay telehealth practice offering compounded GLP-1s, TRT, enclomiphene, women's hormones, ED, hair loss and peptides after a $79 video consult.

Visit ProlongMD
75

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health

Score Breakdown

DimensionProlongMDTwentyeight Health
Overall Score60.1/10075/100 ✓
Trust & Safety30%52/10076/100 ✓
Value25%74/10080/100 ✓
Experience20%55/10072/100 ✓
Product Range15%70/10072/100 ✓
Reputation10%45/10070/100 ✓

At a Glance

Founded20252018
HeadquartersPhoenix, AZBrooklyn, NY
Publicly tradedNoNo
Treatment categories84
Treatments listed137
Starting price$25/mo$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryProlongMDTwentyeight Health
Weight Loss / GLP-1$99–$119
Compounded Semaglutide/B12
—
Women's Health$33
Progesterone (oral)
$15–$19.99
Complete Care Membership
Sexual Health$75
Tadalafil 24 mg
—

ProlongMD

+Low published prices: compounded semaglutide/B12 from $99/mo and tirzepatide/B12 from $149/mo, with no membership fee
+$79 video consult is credited toward the first treatment purchase, and a written price-match policy covers comparable injectable programs
+Names its prescribing clinicians (two physicians, two nurse practitioners) and runs synchronous video visits
−Sells BPC-157/TB-500 and GHK-Cu/BPC-157/KPV/TB-500 'peptide blends', compounds the FDA has flagged for safety concerns and which have no approved drug form
−Dispensing pharmacies are not named, and the states served are not published (visible reviews come only from TX and CO)
−Very new (LLC formed August 2025) with no independent review footprint; several on-site star ratings have no review text
Read the full ProlongMD review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

ProlongMD vs Twentyeight Health — FAQ

Is ProlongMD better than Twentyeight Health?

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Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 60.1/100), leading on trust & safety, value, experience, product range, reputation.

Is ProlongMD or Twentyeight Health cheaper?

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Twentyeight Health has the lower starting price (from $15/mo vs $25/mo for ProlongMD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do ProlongMD and Twentyeight Health both offer?

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Both platforms treat Weight Loss / GLP-1, Women's Health, Sexual Health. ProlongMD covers 8 treatment categories total and Twentyeight Health covers 4.

Still deciding?

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