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ProlongMD vs Yucca Health: Which Is Better?

Head-to-head comparison of ProlongMD and Yucca Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Yucca Health scores higher overall in our independent evaluation (68.3/100 vs 60.1/100), leading on trust & safety, value, experience, reputation. ProlongMD comes out ahead on product range. ProlongMD has the lower entry price (from $25/mo vs $125/mo), so the better value depends on which treatment you need.

60

Small, veteran-owned cash-pay telehealth practice offering compounded GLP-1s, TRT, enclomiphene, women's hormones, ED, hair loss and peptides after a $79 video consult.

Visit ProlongMD
68

Yucca Health is a Beverly Hills-based telehealth platform selling compounded semaglutide and tirzepatide at flat, dose-independent prices, plus compounded NAD+ and sermorelin.

Visit Yucca Health

Score Breakdown

DimensionProlongMDYucca Health
Overall Score60.1/10068.3/100 ✓
Trust & Safety30%52/10064/100 ✓
Value25%74/10080/100 ✓
Experience20%55/10072/100 ✓
Product Range15%70/100 ✓58/100
Reputation10%45/10060/100 ✓

At a Glance

Founded20252025
HeadquartersPhoenix, AZBeverly Hills, CA
Publicly tradedNoNo
Treatment categories82
Treatments listed134
Starting price$25/mo$125/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryProlongMDYucca Health
Weight Loss / GLP-1$99–$119
Compounded Semaglutide/B12
$125–$146
Compounded Semaglutide+ (injectable)
Longevity & Peptides$179
Sermorelin
$158–$215
NAD+ Injection

ProlongMD

+Low published prices: compounded semaglutide/B12 from $99/mo and tirzepatide/B12 from $149/mo, with no membership fee
+$79 video consult is credited toward the first treatment purchase, and a written price-match policy covers comparable injectable programs
+Names its prescribing clinicians (two physicians, two nurse practitioners) and runs synchronous video visits
−Sells BPC-157/TB-500 and GHK-Cu/BPC-157/KPV/TB-500 'peptide blends', compounds the FDA has flagged for safety concerns and which have no approved drug form
−Dispensing pharmacies are not named, and the states served are not published (visible reviews come only from TX and CO)
−Very new (LLC formed August 2025) with no independent review footprint; several on-site star ratings have no review text
Read the full ProlongMD review →

Yucca Health

+Full price grid published before intake: semaglutide $146/mo monthly, $140/mo quarterly or $125/mo on a 6-month prepay; tirzepatide $258, $248 or $225/mo
+Locked pricing covers the whole dose range, so titrating up does not raise the bill; pausing keeps the locked rate
+No separate membership or consultation fee; plans include the provider consult, medication, injection supplies and free 2-day shipping
−Dispensing pharmacies are not named on the public site; they appear only in the patient portal and on the label after ordering
−BBB rating of C+ (not accredited) with five closed complaints; one Trustpilot reviewer reports prepaying six months and receiving three
−About 6% of roughly 1,230 Trustpilot reviews are 1-star, citing lack of results after months of treatment and refund disputes
Read the full Yucca Health review →

ProlongMD vs Yucca Health — FAQ

Is ProlongMD better than Yucca Health?

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Yucca Health scores higher overall in our independent evaluation (68.3/100 vs 60.1/100), leading on trust & safety, value, experience, reputation. ProlongMD comes out ahead on product range. ProlongMD has the lower entry price (from $25/mo vs $125/mo), so the better value depends on which treatment you need.

Is ProlongMD or Yucca Health cheaper?

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ProlongMD has the lower starting price (from $25/mo vs $125/mo for Yucca Health). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do ProlongMD and Yucca Health both offer?

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Both platforms treat Weight Loss / GLP-1, Longevity & Peptides. ProlongMD covers 8 treatment categories total and Yucca Health covers 2.

Still deciding?

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