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Rex MD vs Twentyeight Health: Which Is Better?

Head-to-head comparison of Rex MD and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 72.2/100), leading on value, experience. Rex MD comes out ahead on trust & safety, product range, reputation. Rex MD has the lower entry price (from $2/mo vs $15/mo), so the better value depends on which treatment you need.

Rex MD

Good

Rex MD is a men's-health telehealth brand — owned by publicly traded LifeMD — covering ED, premature ejaculation, TRT, hair loss, and GLP-1 treatment.

Visit Rex MD

Twentyeight Health

Very Good

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health

Score Breakdown

Dimension	Rex MD	Twentyeight Health
Overall Score	72.2/100	75/100 ✓
Trust & Safety30%	78/100 ✓	76/100
Value25%	65/100	80/100 ✓
Experience20%	68/100	72/100 ✓
Product Range15%	78/100 ✓	72/100
Reputation10%	72/100 ✓	70/100

At a Glance

Founded	2019	2018
Headquarters	New York, NY	Brooklyn, NY
Publicly traded	No	No
Treatment categories	5	4
Treatments listed	6	7
Starting price	$2/mo	$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

Category	Rex MD	Twentyeight Health
Sexual Health	$2–$90 Sildenafil / Tadalafil (generic & brand)	—
Weight Loss / GLP-1	$199–$399 GLP-1 Weight Loss	—

Rex MD

+Backed by LifeMD, a publicly traded parent company, giving it more financial and compliance infrastructure than an independent startup

+Strong Trustpilot rating (4.7/5, 5,259 reviews) with consistent praise for customer service staff

+Wide medication range across ED, premature ejaculation, TRT, hair loss, and GLP-1s under one account

−Recurring patient complaints about surprise auto-renewal charges not clearly disclosed at checkout

−Shipping and fulfillment issues reported, including incorrect dosing and underfilled vials

−Headline 'as low as $2/dose' pricing is a teaser rate; full pricing isn't shown until after intake

Read the full Rex MD review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance

+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do

+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours

−Medications are billed separately from the membership, which some reviewers say caused unexpected charges

−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states

−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems

Read the full Twentyeight Health review →

Rex MD vs Twentyeight Health — FAQ

Is Rex MD better than Twentyeight Health?

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Is Rex MD or Twentyeight Health cheaper?

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Rex MD has the lower starting price (from $2/mo vs $15/mo for Twentyeight Health). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Rex MD and Twentyeight Health both offer?

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Both platforms treat Sexual Health, Weight Loss / GLP-1. Rex MD covers 5 treatment categories total and Twentyeight Health covers 4.

Still deciding?

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