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RxSpan MD vs Twentyeight Health: Which Is Better?

Head-to-head comparison of RxSpan MD and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 59.1/100), leading on trust & safety, value, experience, reputation. RxSpan MD comes out ahead on product range.

59

RxSpan MD is a Beverly Hills telehealth practice founded by a plastic surgeon, offering compounded and branded GLP-1s, longevity peptides, hair-loss and ED treatment.

Visit RxSpan MD
75

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health

Score Breakdown

DimensionRxSpan MDTwentyeight Health
Overall Score59.1/10075/100 ✓
Trust & Safety30%60/10076/100 ✓
Value25%58/10080/100 ✓
Experience20%52/10072/100 ✓
Product Range15%78/100 ✓72/100
Reputation10%45/10070/100 ✓

At a Glance

Founded20262018
HeadquartersBeverly Hills, CABrooklyn, NY
Publicly tradedNoNo
Treatment categories44
Treatments listed97
Starting price$30/mo$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryRxSpan MDTwentyeight Health
Weight Loss / GLP-1$249–$299
Compounded Semaglutide (injection or oral)
—
Sexual Health$30–$100
ED (tadalafil, sildenafil/pycnogenol, vardenafil)
—

RxSpan MD

+Physician-founded practice with a named founder and a stated Beverly Hills address
+Offers both compounded (injection and oral) and branded GLP-1s, including cash-pay Zepbound listed at $500
+Third-party coverage reports named 503A pharmacy partners and free expedited shipping
−Compounded prices aren't visible on the public site; its product catalog failed to load during our research
−Brand-stated first-month prices ($249 semaglutide, $329 tirzepatide) are above peer averages, and renewal pricing is not published
−Site configuration shows an $80 initial visit fee that is not prominently disclosed
Read the full RxSpan MD review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

RxSpan MD vs Twentyeight Health — FAQ

Is RxSpan MD better than Twentyeight Health?

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Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 59.1/100), leading on trust & safety, value, experience, reputation. RxSpan MD comes out ahead on product range.

Is RxSpan MD or Twentyeight Health cheaper?

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Twentyeight Health has the lower starting price (from $15/mo vs $30/mo for RxSpan MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do RxSpan MD and Twentyeight Health both offer?

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Both platforms treat Weight Loss / GLP-1, Sexual Health. RxSpan MD covers 4 treatment categories total and Twentyeight Health covers 4.

Still deciding?

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