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Shameless Care vs Twentyeight Health: Which Is Better?

Head-to-head comparison of Shameless Care and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 66/100), leading on trust & safety, value, experience, product range, reputation.

66

Shameless Care is an Illinois sexual-health telehealth company selling ED and female-arousal medications, comprehensive STI testing, DoxyPEP and UTI/BV/yeast treatment as one-time purchases.

Visit Shameless Care
75

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health

Score Breakdown

DimensionShameless CareTwentyeight Health
Overall Score66/10075/100 ✓
Trust & Safety30%68/10076/100 ✓
Value25%68/10080/100 ✓
Experience20%66/10072/100 ✓
Product Range15%66/10072/100 ✓
Reputation10%55/10070/100 ✓

At a Glance

Founded20222018
HeadquartersSt. Charles, ILBrooklyn, NY
Publicly tradedNoNo
Treatment categories44
Treatments listed107
Starting price$63/mo$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryShameless CareTwentyeight Health
Sexual Health$99–$199
DoxyPEP
—
Women's Health$63
UTI / BV / Yeast Infection Treatment
$15–$19.99
Complete Care Membership

Shameless Care

+One-time purchases with no auto-renewal, which avoids the recurring-charge complaints common in the category
+Every price is posted on the site, all-in with consult, prescription and shipping (e.g. UTI treatment $63, Shameless Duo from $130)
+Covers men's and women's sexual health, including STI testing, DoxyPEP, herpes suppression and female arousal treatments, which most ED-focused brands don't
−Two of its three named partner pharmacies (Curexa, Belmar) received FDA compounding warning letters in 2023
−Review evidence is mostly the brand's own on-site testimonials; little independent Trustpilot or Reddit footprint
−Compounded ED troches cost about $7–11 per dose, well above generic sildenafil or tadalafil tablets
Read the full Shameless Care review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

Shameless Care vs Twentyeight Health — FAQ

Is Shameless Care better than Twentyeight Health?

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Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 66/100), leading on trust & safety, value, experience, product range, reputation.

Is Shameless Care or Twentyeight Health cheaper?

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Twentyeight Health has the lower starting price (from $15/mo vs $63/mo for Shameless Care). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Shameless Care and Twentyeight Health both offer?

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Both platforms treat Sexual Health, Women's Health. Shameless Care covers 4 treatment categories total and Twentyeight Health covers 4.

Still deciding?

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