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SkinnyRx vs Twentyeight Health: Which Is Better?

Head-to-head comparison of SkinnyRx and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 57.9/100), leading on trust & safety, value, product range, reputation. SkinnyRx comes out ahead on experience.

58

Cash-pay compounded GLP-1 provider offering five dosing formats, currently facing an FDA warning letter against its parent company.

Visit SkinnyRx
75

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health

Score Breakdown

DimensionSkinnyRxTwentyeight Health
Overall Score57.9/10075/100 ✓
Trust & Safety30%45/10076/100 ✓
Value25%68/10080/100 ✓
Experience20%78/100 ✓72/100
Product Range15%55/10072/100 ✓
Reputation10%35/10070/100 ✓

At a Glance

Founded—2018
Headquarters—Brooklyn, NY
Publicly tradedNoNo
Treatment categories14
Treatments listed47
Starting price$199/mo$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategorySkinnyRxTwentyeight Health
Weight Loss / GLP-1$199
Semaglutide Injection
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SkinnyRx

+Five dosing formats (injection, sublingual, tablet) for semaglutide/tirzepatide give patients flexibility
+Large Trustpilot volume (5,390 reviews) at a 4.8 average suggests broad satisfaction
+Reps cited by name in reviews for responsive onboarding guidance
−FDA warning letter reportedly issued to parent company Lean Rx, Inc. (February 2026) — unverified independently this cycle, needs manual confirmation
−Some patients report oral/sublingual formats were ineffective with no visible results
−A reviewer described being required to pay upfront for medication that had no effect
Read the full SkinnyRx review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

SkinnyRx vs Twentyeight Health — FAQ

Is SkinnyRx better than Twentyeight Health?

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Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 57.9/100), leading on trust & safety, value, product range, reputation. SkinnyRx comes out ahead on experience.

Is SkinnyRx or Twentyeight Health cheaper?

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Twentyeight Health has the lower starting price (from $15/mo vs $199/mo for SkinnyRx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do SkinnyRx and Twentyeight Health both offer?

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Both platforms treat Weight Loss / GLP-1. SkinnyRx covers 1 treatment category total and Twentyeight Health covers 4.

Still deciding?

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