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TelyRx vs Twentyeight Health: Which Is Better?

Head-to-head comparison of TelyRx and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 72.3/100), leading on trust & safety, value, reputation. TelyRx comes out ahead on experience, product range.

72
TelyRx
Good

TelyRx is a publicly listed online pharmacy platform where patients choose from 500+ generic and branded medications and pay a one-time $22 provider-review fee for an asynchronous prescription from an independent, state-licensed clinician.

Visit TelyRx

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health

Score Breakdown

DimensionTelyRxTwentyeight Health
Overall Score72.3/10075/100 ✓
Trust & Safety30%70/10076/100 ✓
Value25%72/10080/100 ✓
Experience20%74/100 ✓72/100
Product Range15%80/100 ✓72/100
Reputation10%65/10070/100 ✓

At a Glance

Founded—2018
HeadquartersClearwater, FLBrooklyn, NY
Publicly tradedYes (TSX: TELY)No
Treatment categories74
Treatments listed97
Starting price$22.99/mo$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryTelyRxTwentyeight Health
Sexual Health$27.99
Generic Sildenafil
—
Women's Health$22.99–$139.99
Birth Control Pills (generic)
$15–$19.99
Complete Care Membership
Dermatology——
Weight Loss / GLP-1$699.99–$1199.99
Branded Zepbound
—

TelyRx

+Every catalog price is visible before signup; the only clinical fee is a one-time $22 provider review
+Owns its licensed retail pharmacies, so fulfilment and pharmacist support stay in-house
+Very broad catalog (500+ medications) that includes chronic-condition generics such as lisinopril, albuterol and metformin, plus birth control, ED and hair loss
−Branded GLP-1s are priced near list (Wegovy from $1,399.99), well above manufacturer self-pay programs
−Prescribing is questionnaire-only and done by independent providers, with no ongoing clinical relationship
−Recurring complaints about shipping delays and refills charged without the patient's authorization
Read the full TelyRx review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

TelyRx vs Twentyeight Health — FAQ

Is TelyRx better than Twentyeight Health?

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Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 72.3/100), leading on trust & safety, value, reputation. TelyRx comes out ahead on experience, product range.

Is TelyRx or Twentyeight Health cheaper?

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Twentyeight Health has the lower starting price (from $15/mo vs $22.99/mo for TelyRx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do TelyRx and Twentyeight Health both offer?

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Both platforms treat Sexual Health, Women's Health, Dermatology, Weight Loss / GLP-1. TelyRx covers 7 treatment categories total and Twentyeight Health covers 4.

Still deciding?