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TrimRx vs Twentyeight Health: Which Is Better?

Head-to-head comparison of TrimRx and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 52/100), leading on trust & safety, value, experience, product range, reputation.

52
TrimRx
Below Average

San Diego-based GLP-1 weight loss telehealth offering compounded semaglutide and tirzepatide at $179-349/month.

Visit TrimRx
75

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health

Score Breakdown

DimensionTrimRxTwentyeight Health
Overall Score52/10075/100 ✓
Trust & Safety30%55/10076/100 ✓
Value25%70/10080/100 ✓
Experience20%45/10072/100 ✓
Product Range15%30/10072/100 ✓
Reputation10%45/10070/100 ✓

At a Glance

Founded20242018
HeadquartersSan Diego, CABrooklyn, NY
Publicly tradedNoNo
Treatment categories14
Treatments listed87
Starting price$179/mo$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryTrimRxTwentyeight Health
Weight Loss / GLP-1$179–$329
Compounded Semaglutide (Oral/Sublingual)
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TrimRx

+70-85% savings vs brand-name GLP-1s: semaglutide at $199/mo vs $1,000+ retail
+Not included in FDA's 2025 warning letter wave — clean regulatory record
+Multiple delivery formats: injectable, oral tablet, and sublingual drops
−Branded pages advertise 'In Stock' with a price while the same page states TrimRx does not sell, dispense or ship branded medication and the patient pays a pharmacy directly
−Cancellation difficulties: long phone waits, reports of being hung up on; dedicated JoinChargeback page exists
−Strict no-refund policy once medical intake is submitted, even before medication ships
Read the full TrimRx review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

TrimRx vs Twentyeight Health — FAQ

Is TrimRx better than Twentyeight Health?

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Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 52/100), leading on trust & safety, value, experience, product range, reputation.

Is TrimRx or Twentyeight Health cheaper?

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Twentyeight Health has the lower starting price (from $15/mo vs $179/mo for TrimRx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do TrimRx and Twentyeight Health both offer?

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Both platforms treat Weight Loss / GLP-1. TrimRx covers 1 treatment category total and Twentyeight Health covers 4.

Still deciding?

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