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Twentyeight Health vs Wellmedr: Which Is Better?

Head-to-head comparison of Twentyeight Health and Wellmedr based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 60.8/100), leading on trust & safety, value, experience, reputation.

75

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health
61

Wellmedr is a St. Petersburg, FL telehealth brand launched in 2025. It sells low-priced compounded semaglutide and tirzepatide plus ED, enclomiphene, hair-loss and NAD+ treatments, prescribed through OpenLoop Health.

Visit Wellmedr

Score Breakdown

DimensionTwentyeight HealthWellmedr
Overall Score75/100 ✓60.8/100
Trust & Safety30%76/100 ✓50/100
Value25%80/100 ✓78/100
Experience20%72/100 ✓55/100
Product Range15%72/10072/100
Reputation10%70/100 ✓45/100

At a Glance

Founded20182025
HeadquartersBrooklyn, NYSt. Petersburg, FL
Publicly tradedNoNo
Treatment categories46
Treatments listed76
Starting price$15/mo$40/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryTwentyeight HealthWellmedr
Sexual Health—$60–$120
Black Pill 3-in-1 (sildenafil/tadalafil/apomorphine)
Weight Loss / GLP-1—$49–$149
Compounded Semaglutide (+NAD+/B12)

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

Wellmedr

+Some of the lowest compounded GLP-1 prices we track: $49/mo semaglutide and $89/mo tirzepatide on 12-month plans, the same at every dose
+Broad catalog for a new brand, spanning GLP-1s, a 3-in-1 ED pill, enclomiphene, a 4-in-1 hair-loss formula and NAD+
+Unlimited clinician messaging and 1–4 hour approval target; 90-day money-back guarantee advertised
−BBB rating of F with 75 complaints since its May 2025 start; BBB flagged a pattern of late or temperature-mishandled deliveries, charges after cancellation and refused guarantee refunds
−Reviewers report billing every 21 days rather than monthly, which adds charges over a year
−Dispensing pharmacies are not named, and prescribing is outsourced to OpenLoop Health and 'other networks'
Read the full Wellmedr review →

Twentyeight Health vs Wellmedr — FAQ

Is Twentyeight Health better than Wellmedr?

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Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 60.8/100), leading on trust & safety, value, experience, reputation.

Is Twentyeight Health or Wellmedr cheaper?

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Twentyeight Health has the lower starting price (from $15/mo vs $40/mo for Wellmedr). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Twentyeight Health and Wellmedr both offer?

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Both platforms treat Sexual Health, Weight Loss / GLP-1. Twentyeight Health covers 4 treatment categories total and Wellmedr covers 6.

Still deciding?

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