Home›Compare›Twentyeight Health vs Yucca Health

Twentyeight Health vs Yucca Health: Which Is Better?

Head-to-head comparison of Twentyeight Health and Yucca Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 68.3/100), leading on trust & safety, product range, reputation.

75

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health
68

Yucca Health is a Beverly Hills-based telehealth platform selling compounded semaglutide and tirzepatide at flat, dose-independent prices, plus compounded NAD+ and sermorelin.

Visit Yucca Health

Score Breakdown

DimensionTwentyeight HealthYucca Health
Overall Score75/100 ✓68.3/100
Trust & Safety30%76/100 ✓64/100
Value25%80/10080/100
Experience20%72/10072/100
Product Range15%72/100 ✓58/100
Reputation10%70/100 ✓60/100

At a Glance

Founded20182025
HeadquartersBrooklyn, NYBeverly Hills, CA
Publicly tradedNoNo
Treatment categories42
Treatments listed74
Starting price$15/mo$125/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryTwentyeight HealthYucca Health
Weight Loss / GLP-1—$125–$146
Compounded Semaglutide+ (injectable)

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

Yucca Health

+Full price grid published before intake: semaglutide $146/mo monthly, $140/mo quarterly or $125/mo on a 6-month prepay; tirzepatide $258, $248 or $225/mo
+Locked pricing covers the whole dose range, so titrating up does not raise the bill; pausing keeps the locked rate
+No separate membership or consultation fee; plans include the provider consult, medication, injection supplies and free 2-day shipping
−Dispensing pharmacies are not named on the public site; they appear only in the patient portal and on the label after ordering
−BBB rating of C+ (not accredited) with five closed complaints; one Trustpilot reviewer reports prepaying six months and receiving three
−About 6% of roughly 1,230 Trustpilot reviews are 1-star, citing lack of results after months of treatment and refund disputes
Read the full Yucca Health review →

Twentyeight Health vs Yucca Health — FAQ

Is Twentyeight Health better than Yucca Health?

▾

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 68.3/100), leading on trust & safety, product range, reputation.

Is Twentyeight Health or Yucca Health cheaper?

▾

Twentyeight Health has the lower starting price (from $15/mo vs $125/mo for Yucca Health). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Twentyeight Health and Yucca Health both offer?

▾

Both platforms treat Weight Loss / GLP-1. Twentyeight Health covers 4 treatment categories total and Yucca Health covers 2.

Still deciding?

Twentyeight Health alternativesYucca Health alternativesTake the Match Quiz