Low-dose naltrexone (LDN) Online
Low-dose naltrexone (LDN) uses naltrexone — an FDA-approved opioid antagonist for alcohol and opioid use disorder at 50 mg — at roughly one-tenth the dose, typically 0.5–4.5 mg daily. It is prescribed off-label for chronic pain conditions such as fibromyalgia, and for some inflammatory and autoimmune conditions. LDN is usually compounded, because no commercial product comes in these strengths. Evidence comes from small trials with mixed results.
How Low-dose naltrexone (LDN) Works
At low doses, naltrexone briefly blocks opioid receptors, which is thought to trigger a compensatory rise in the body's own endorphins. It also blocks Toll-like receptor 4 on microglia, the immune cells of the nervous system, which may reduce neuroinflammation. Small randomized trials in fibromyalgia reported modest pain reductions, though a larger Danish randomized trial (FINAL, published 2024) found no significant benefit over placebo. Small studies in Crohn's disease, multiple sclerosis, and long COVID have been encouraging but are not definitive.
What to Expect
Usually started at a low dose and increased gradually over several weeks. Most protocols suggest a trial of 2–3 months to judge whether it helps.
Low-dose naltrexone (LDN) Pricing Comparison
Sorted by lowest starting price.
Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.
| Provider | Score | Product | Price/mo | Includes | |
|---|---|---|---|---|---|
| LDN Doctor | 60 | Low-Dose Naltrexone Consult + 6-month Rx | $17–$30 $220 first consult (6-month Rx); $130 returning consult; medication paid to pharmacy separately | ○ Consults○ Shipping○ Labs | Visit |
| AgelessRx | 73 | Low Dose Naltrexone (LDN) | $25–$45 | ● Consults● Shipping○ Labs | Visit |
| Healthspan | 71 | Low-Dose Naltrexone (capsule or troche) | $65–$99 | ● Consults● Shipping○ Labs | Visit |
| Invigor Medical | 62 | Low Dose Naltrexone | $180 | ● Consults● Shipping○ Labs | Visit |
Common Side Effects
- •Vivid dreams
- •Trouble sleeping (often managed by switching to morning dosing)
- •Headache
- •Nausea
- •Mild anxiety or irritability early in treatment
Serious Side Effects
- !Precipitated opioid withdrawal in anyone taking opioids
- !Loss of pain relief from opioid medications in an emergency
- !Liver injury (reported at standard 50 mg+ doses; rare at low doses)
Low-dose naltrexone (LDN) Is Not For
- ✗Anyone taking opioid medications, including tramadol and buprenorphine
- ✗People with acute hepatitis or liver failure
- ✗People who may need opioid pain control soon, such as before planned surgery (tell your surgical team)
Low-dose naltrexone (LDN) — Frequently Asked Questions
Is low-dose naltrexone FDA-approved?
▾
Naltrexone is FDA-approved at 50 mg for alcohol and opioid use disorder. Using it at low doses for pain, inflammation, or autoimmune conditions is off-label, and low-dose capsules or liquids are generally compounded.
What conditions is LDN used for?
▾
Most commonly fibromyalgia and other chronic pain conditions, and less often Crohn's disease, multiple sclerosis, and long COVID symptoms. The evidence is from small studies and is mixed; it is best considered a low-cost, low-side-effect option to try under supervision, not an established treatment.
How much does LDN cost?
▾
The compounded medication itself is inexpensive, often about $30–60 per month. Telehealth programs that include the consultation typically charge about $40–100 per month.
Is LDN used for weight loss?
▾
Naltrexone combined with bupropion (Contrave) is an FDA-approved weight-loss medication, but that uses standard-dose naltrexone. Low-dose naltrexone on its own has no good evidence for weight loss.
Medical disclaimer: The information on this page is for educational purposes only and is not medical advice.Low-dose naltrexone (LDN) requires a prescription from a licensed healthcare provider. Side effects, risks, and suitability vary by individual. Always consult your doctor before starting, stopping, or changing any medication. TelehealthMatch is not a healthcare provider.
Not sure which provider is right for you?
Take the Match Quiz