Progesterone Online
Brand names: Prometrium
Progesterone is a bioidentical hormone used alongside estrogen in HRT for women with an intact uterus. It protects the uterine lining from thickening caused by estrogen, reducing the risk of endometrial cancer. Available as oral capsules or transdermal cream.
How Progesterone Works
When estrogen is taken alone, it stimulates growth of the uterine lining (endometrium), which can lead to hyperplasia and increase cancer risk. Progesterone counteracts this by stabilizing the endometrium and triggering periodic shedding. It also has calming effects on the nervous system, which can help with sleep.
What to Expect
Progesterone's protective effects on the uterine lining begin immediately. Sleep improvements from the calming effect are often noticed within the first few days of use. It is taken continuously or cyclically depending on the HRT protocol prescribed.
Progesterone Pricing Comparison
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Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.
Common Side Effects
- •Drowsiness (which is why it's often taken at bedtime)
- •Bloating
- •Breast tenderness
- •Mood changes
- •Headache
Serious Side Effects
- !Blood clots (risk is lower with bioidentical progesterone than synthetic progestins)
- !Depression (in some women)
- !Allergic reaction (progesterone capsules contain peanut oil — not suitable for peanut allergy)
Progesterone Is Not For
- ✗Women with peanut allergy (oral Prometrium contains peanut oil)
- ✗Women with active blood clots
- ✗Women with severe liver disease
- ✗Women with known progesterone-sensitive cancers
Progesterone — Frequently Asked Questions
Why is progesterone prescribed with estrogen?
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Women with an intact uterus who take estrogen must also take progesterone to protect against endometrial hyperplasia (thickening of the uterine lining), which can increase cancer risk.
What is the difference between progesterone and progestin?
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Progesterone (like Prometrium) is bioidentical — chemically identical to what your body produces. Progestins (like medroxyprogesterone) are synthetic versions. Most telehealth HRT providers prefer bioidentical progesterone due to a better side effect profile and emerging evidence of lower cardiovascular risk.
Medical disclaimer: The information on this page is for educational purposes only and is not medical advice.Progesterone requires a prescription from a licensed healthcare provider. Side effects, risks, and suitability vary by individual. Always consult your doctor before starting, stopping, or changing any medication. TelehealthMatch is not a healthcare provider.
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