Semaglutide Online
Brand names: Ozempic, Wegovy, Rybelsus
Semaglutide is a GLP-1 receptor agonist originally developed for type 2 diabetes that has become one of the most prescribed weight loss medications in the U.S. It works by mimicking a hormone that regulates appetite and blood sugar, leading to reduced hunger and significant weight loss in clinical trials.
How Semaglutide Works
Semaglutide mimics GLP-1, a hormone your gut releases after eating. It slows gastric emptying (so you feel full longer), reduces appetite signals in the brain, and improves insulin sensitivity. The result is reduced caloric intake without the constant hunger that derails most diets. In clinical trials, patients lost an average of 15-17% of body weight over 68 weeks.
What to Expect
Most patients notice reduced appetite within the first 1-2 weeks. Measurable weight loss typically begins by week 4-8. Full effects are usually seen after 6-12 months of consistent use at the maintenance dose. Dosing starts low and increases gradually over 16-20 weeks to minimize side effects.
Semaglutide Pricing Comparison
Sorted by lowest starting price.
Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.
| Provider | Score | Product | Price/mo | Includes | |
|---|---|---|---|---|---|
| Noom | 60 | Noom Med GLP-1 Rx (Compounded Semaglutide) | $129–$279 $129 first 4-week supply | ● Consults● Shipping○ Labs | Visit |
| Noom Microdose GLP-1 Rx | $49–$179 $49 first 4-week supply (limited-time) | ● Consults● Shipping○ Labs | |||
| Proactive Health Microdose GLP-1Rx | $149 Includes biomarker testing kit; 4-month subscription | ● Consults● Shipping● Labs | |||
| Fridays | 55 | Compounded Semaglutide | $150–$249 $100 off any plan via codes; up to 58% off first order; buy 3 months get 1 free | ● Consults● Shipping● Labs | Visit |
| Branded Wegovy (Pill or Pen) | $98 $49 first month; $98/mo on prepaid annual plan | ● Consults● Shipping● Labs | |||
| Brand-name Ozempic | $1498 | ● Consults● Shipping● Labs | |||
| Hims & Hers | 78 | Branded Wegovy (oral/injectable) | $149–$299 Wegovy pill from $149/mo | ● Consults● Shipping○ Labs | Visit |
| Ro | 77 | Branded Wegovy Pill (oral semaglutide) | $149–$299 4mg dose $149/mo limited-time (reg. $199) | ○ Consults● Shipping○ Labs | Visit |
| Branded Wegovy Pen | $199–$399 Starter doses $199/mo limited-time (reg. $349) | ○ Consults● Shipping○ Labs | |||
| Sesame Care | 74 | Oral Wegovy Program | $149 | ● Consults● Shipping○ Labs | Visit |
| LifeMD | 68 | Branded Wegovy (oral/injectable) | $149–$349 Wegovy pill from $149/mo; pen $199 first 2 fills; program fee $39 first month (then $149/mo) | ○ Consults● Shipping○ Labs | Visit |
| Ivim Health | 58 | Compounded Semaglutide (12-month plan) | $150–$175 First month membership free | ● Consults● Shipping○ Labs | Visit |
| Compounded Semaglutide (6-month plan) | $175 First month membership free | ● Consults● Shipping○ Labs | |||
| Shed | 67 | Compounded Semaglutide (injectable) | $159–$199 $159/mo on 12-month plan, $179/mo on 6-month | ● Consults● Shipping○ Labs | Visit |
| GLP-1 Drops / Lozenges | $199–$229 | ● Consults● Shipping○ Labs | |||
| Branded Wegovy / Zepbound | $274–$624 Medication ($149-499, paid to pharmacy) + $125/mo membership; Wegovy pill from $149/mo | ● Consults● Shipping○ Labs | |||
| Mochi Health | 67 | Compounded Semaglutide (All Doses) | $178 $39 first month membership (vs $79); current promo: med $60/mo (reg. $99) | ● Consults● Shipping○ Labs | Visit |
| Direct Meds | 74 | Compounded Semaglutide (sublingual) | $179–$249 | ● Consults● Shipping○ Labs | Visit |
| Compounded Semaglutide (injectable) | $297 | ● Consults● Shipping○ Labs | |||
| MEDVi | 71 | Compounded Semaglutide (Injectable) | $179–$299 $179 first month | ● Consults● Shipping○ Labs | Visit |
| Compounded Semaglutide (Oral) | $249–$369 $249 first month | ● Consults● Shipping○ Labs | |||
| TrimRx | 52 | Compounded Semaglutide (Injectable) | $199–$349 $199 first month (reg. $299-349 after) | ● Consults● Shipping○ Labs | Visit |
| Compounded Semaglutide (Oral/Sublingual) | $179–$329 $179 first month (reg. $329 after) | ● Consults● Shipping○ Labs | |||
| Brand-name Ozempic | $1299 | ● Consults● Shipping○ Labs | |||
| Remedy Meds | 69 | Compounded Semaglutide | $299 $179 first month; price-lock guarantee | ● Consults● Shipping● Labs | Visit |
| GLP-1 Microdose Plan | $189 | ● Consults● Shipping○ Labs | |||
| Eden | 64 | Compounded Semaglutide (Injectable) | $198 First month $138 ($99 med + $39 membership); membership $99/mo after | ● Consults● Shipping○ Labs | Visit |
| Male Excel | 62 | Semaglutide Weight Loss | $499 First month $299 (save $200) | ● Consults● Shipping○ Labs | Visit |
| eMed | 67 | GLP-1 Weight Management Program | $649–$1399 $99/mo program fee + medication cost ($550–$1,300/mo) | ● Consults● Shipping● Labs | Visit |
Common Side Effects
- •Nausea (most common, especially during dose escalation)
- •Diarrhea or constipation
- •Vomiting
- •Abdominal pain or bloating
- •Headache
- •Fatigue
- •Injection site reactions (for injectable form)
Serious Side Effects
- !Pancreatitis (seek immediate medical attention for severe abdominal pain)
- !Gallbladder problems
- !Kidney injury from dehydration due to vomiting/diarrhea
- !Risk of thyroid C-cell tumors (observed in animal studies)
- !Hypoglycemia when combined with insulin or sulfonylureas
Semaglutide Is Not For
- ✗People with a personal or family history of medullary thyroid carcinoma
- ✗People with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- ✗People with a history of pancreatitis
- ✗Pregnant or breastfeeding women
Semaglutide — Frequently Asked Questions
What is the difference between compounded and brand-name semaglutide?
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Brand-name semaglutide (Ozempic, Wegovy) is manufactured by Novo Nordisk and FDA-approved. Compounded semaglutide is made by compounding pharmacies and is typically much cheaper ($150-300/mo vs $1,000+/mo) but carries different regulatory oversight. The FDA has taken enforcement actions against some compounders, so sourcing matters.
How much does semaglutide cost through telehealth?
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Through telehealth providers, compounded semaglutide typically costs $149-499/month depending on the provider and dosage. Brand-name semaglutide (Wegovy) costs $1,000+/month without insurance, though some telehealth platforms like Ro have partnerships that offer lower pricing.
Is semaglutide a weekly or daily medication?
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Injectable semaglutide (the most common form through telehealth) is a once-weekly injection. Oral semaglutide (Rybelsus) is taken daily. Some compounding pharmacies also offer sublingual (under the tongue) forms.
Do I need a prescription for semaglutide?
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Yes, semaglutide requires a prescription from a licensed medical provider. Telehealth platforms connect you with providers who can evaluate you online and prescribe it if appropriate. The consultation is typically included in the monthly cost.
What happens when I stop taking semaglutide?
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Clinical studies show that most patients regain a significant portion of lost weight within a year of stopping semaglutide. This is because the medication suppresses appetite while active — it does not permanently change metabolism. Many providers recommend building sustainable lifestyle habits while on the medication.
How do I inject semaglutide?
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Semaglutide is injected subcutaneously (under the skin) once a week, typically in the abdomen, thigh, or upper arm. Most telehealth providers ship pre-filled pens or vials with syringes and injection instructions. The needle is very small and most patients describe minimal discomfort.
Medical disclaimer: The information on this page is for educational purposes only and is not medical advice.Semaglutide requires a prescription from a licensed healthcare provider. Side effects, risks, and suitability vary by individual. Always consult your doctor before starting, stopping, or changing any medication. TelehealthMatch is not a healthcare provider.
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