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AgelessRx vs Defy Medical: Which Is Better?

Head-to-head comparison of AgelessRx and Defy Medical based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

AgelessRx scores higher overall in our independent evaluation (73.4/100 vs 71.9/100), leading on value, product range. Defy Medical comes out ahead on experience, reputation.

73

AgelessRx is an Ann Arbor-based longevity telehealth company that prescribes rapamycin, metformin, low-dose naltrexone and NAD+, and also sells compounded and branded GLP-1s.

Visit AgelessRx
72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

Visit Defy Medical

Score Breakdown

DimensionAgelessRxDefy Medical
Overall Score73.4/100 ✓71.9/100
Trust & Safety30%72/10072/100
Value25%74/100 ✓60/100
Experience20%70/10078/100 ✓
Product Range15%82/100 ✓78/100
Reputation10%70/10080/100 ✓

At a Glance

Founded20192011
HeadquartersAnn Arbor, MITampa, FL
Publicly tradedNoNo
Treatment categories43
Treatments listed144
Starting price$25/mo$150/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryAgelessRxDefy Medical
Weight Loss / GLP-1$99
Microdosing Semaglutide
$150–$250
GLP-1 Weight Loss (Semaglutide/Tirzepatide)
Hormone Therapy$50
Women's Hormone Care
$150–$250
Women's Bioidentical HRT

AgelessRx

+Deepest longevity formulary we track: rapamycin ($65/mo), metformin and LDN ($25/mo), NAD+, sermorelin, glutathione and B12
+Research-led: publishes a named medical director and runs its own decentralised trials (e.g. PEARL rapamycin study)
+Low entry prices with video visits and shipping included and no separate membership fee
−No consolidated price list; GLP-1 and NAD+ prices vary widely by plan length ($79 vs $235/mo reported for NAD+ injections)
−Headline microdosed tirzepatide price ($159/mo) requires a four-month plan billed upfront (~$636)
−Reviewers report slow support replies, billing/card-decline errors and heavy marketing email
Read the full AgelessRx review →

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

AgelessRx vs Defy Medical — FAQ

Is AgelessRx better than Defy Medical?

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AgelessRx scores higher overall in our independent evaluation (73.4/100 vs 71.9/100), leading on value, product range. Defy Medical comes out ahead on experience, reputation.

Is AgelessRx or Defy Medical cheaper?

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AgelessRx has the lower starting price (from $25/mo vs $150/mo for Defy Medical). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do AgelessRx and Defy Medical both offer?

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Both platforms treat Weight Loss / GLP-1, Hormone Therapy. AgelessRx covers 4 treatment categories total and Defy Medical covers 3.

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