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AgelessRx vs Josie: Which Is Better?

Head-to-head comparison of AgelessRx and Josie based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

AgelessRx scores higher overall in our independent evaluation (73.4/100 vs 57.6/100), leading on trust & safety, value, experience, product range, reputation.

73

AgelessRx is an Ann Arbor-based longevity telehealth company that prescribes rapamycin, metformin, low-dose naltrexone and NAD+, and also sells compounded and branded GLP-1s.

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58
Josie
Fair

Small menopause-focused telehealth brand selling compounded and branded GLP-1s, microdose GLP-1 maintenance plans and estradiol/progesterone HRT at flat published prices.

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Score Breakdown

DimensionAgelessRxJosie
Overall Score73.4/100 ✓57.6/100
Trust & Safety30%72/100 ✓50/100
Value25%74/100 ✓70/100
Experience20%70/100 ✓58/100
Product Range15%82/100 ✓60/100
Reputation10%70/100 ✓45/100

At a Glance

Founded2019—
HeadquartersAnn Arbor, MI—
Publicly tradedNoNo
Treatment categories43
Treatments listed147
Starting price$25/mo$90/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryAgelessRxJosie
Weight Loss / GLP-1$99
Microdosing Semaglutide
$189
Microdose GLP-1 Maintenance (semaglutide or tirzepatide)
Hormone Therapy$50
Women's Hormone Care
$90–$100
Estradiol Patch or Cream (HRT)
Women's Health——

AgelessRx

+Deepest longevity formulary we track: rapamycin ($65/mo), metformin and LDN ($25/mo), NAD+, sermorelin, glutathione and B12
+Research-led: publishes a named medical director and runs its own decentralised trials (e.g. PEARL rapamycin study)
+Low entry prices with video visits and shipping included and no separate membership fee
−No consolidated price list; GLP-1 and NAD+ prices vary widely by plan length ($79 vs $235/mo reported for NAD+ injections)
−Headline microdosed tirzepatide price ($159/mo) requires a four-month plan billed upfront (~$636)
−Reviewers report slow support replies, billing/card-decline errors and heavy marketing email
Read the full AgelessRx review →

Josie

+Flat pricing at any dose, published before intake: compounded semaglutide $249/mo ($194/mo prepaid annually), tirzepatide $349/mo ($233/mo annually)
+Offers injectable, oral ODT and microdose ($189/mo) GLP-1 formats alongside HRT in one women's-midlife intake
+Names its lead clinician (Dr. Ana Lisa Carr, MD, board-certified in family medicine) and says it serves all 50 states
−FDA warning letter (Feb 20, 2026) for misbranded compounded semaglutide/tirzepatide marketing
−White-label setup: Josie is a trade name of One Eleven Nutrition LLC on the CareValidate platform, and its terms say it doesn't control provider decisions
−An $80 consultation fee applies if a provider approves a plan and the patient declines medication, and filled orders are non-refundable
Read the full Josie review →

AgelessRx vs Josie — FAQ

Is AgelessRx better than Josie?

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AgelessRx scores higher overall in our independent evaluation (73.4/100 vs 57.6/100), leading on trust & safety, value, experience, product range, reputation.

Is AgelessRx or Josie cheaper?

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AgelessRx has the lower starting price (from $25/mo vs $90/mo for Josie). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do AgelessRx and Josie both offer?

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Both platforms treat Weight Loss / GLP-1, Hormone Therapy, Women's Health. AgelessRx covers 4 treatment categories total and Josie covers 3.

Still deciding?

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