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AgelessRx vs Natural Cycles: Which Is Better?

Head-to-head comparison of AgelessRx and Natural Cycles based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

AgelessRx scores higher overall in our independent evaluation (73.4/100 vs 67.4/100), leading on trust & safety, product range, reputation. Natural Cycles comes out ahead on value, experience. Natural Cycles has the lower entry price (from $12.5/mo vs $25/mo), so the better value depends on which treatment you need.

73

AgelessRx is an Ann Arbor-based longevity telehealth company that prescribes rapamycin, metformin, low-dose naltrexone and NAD+, and also sells compounded and branded GLP-1s.

Visit AgelessRx
67

FDA-cleared, hormone-free digital contraceptive that uses temperature data from a thermometer or wearable to flag fertile days; it involves no clinician or prescription.

Visit Natural Cycles

Score Breakdown

DimensionAgelessRxNatural Cycles
Overall Score73.4/100 ✓67.4/100
Trust & Safety30%72/100 ✓70/100
Value25%74/10076/100 ✓
Experience20%70/10072/100 ✓
Product Range15%82/100 ✓45/100
Reputation10%70/100 ✓62/100

At a Glance

Founded20192013
HeadquartersAnn Arbor, MIStockholm, Sweden
Publicly tradedNoNo
Treatment categories41
Treatments listed141
Starting price$25/mo$12.5/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryAgelessRxNatural Cycles
Women's Health—$12.5
NC° Birth Control (annual plan incl. NC° Band)

AgelessRx

+Deepest longevity formulary we track: rapamycin ($65/mo), metformin and LDN ($25/mo), NAD+, sermorelin, glutathione and B12
+Research-led: publishes a named medical director and runs its own decentralised trials (e.g. PEARL rapamycin study)
+Low entry prices with video visits and shipping included and no separate membership fee
−No consolidated price list; GLP-1 and NAD+ prices vary widely by plan length ($79 vs $235/mo reported for NAD+ injections)
−Headline microdosed tirzepatide price ($159/mo) requires a four-month plan billed upfront (~$636)
−Reviewers report slow support replies, billing/card-decline errors and heavy marketing email
Read the full AgelessRx review →

Natural Cycles

+Only FDA-cleared digital contraceptive (Class II De Novo, 2018), with no hormones or side effects
+Low all-in cost: about $150/year including the NC° Band wearable, HSA/FSA-eligible
+Works with existing wearables (Oura, Apple Watch Series 8+, Garmin) and switches between contraception, conception, pregnancy, postpartum and perimenopause modes at no extra charge
−Typical-use effectiveness is 93%, below IUDs and implants, and depends on daily measurement and abstaining or using protection on fertile days
−No clinician involvement or prescription options; not a substitute for a birth-control prescriber
−December 2025 class action alleges reproductive-health data was shared with third-party trackers without consent
Read the full Natural Cycles review →

AgelessRx vs Natural Cycles — FAQ

Is AgelessRx better than Natural Cycles?

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AgelessRx scores higher overall in our independent evaluation (73.4/100 vs 67.4/100), leading on trust & safety, product range, reputation. Natural Cycles comes out ahead on value, experience. Natural Cycles has the lower entry price (from $12.5/mo vs $25/mo), so the better value depends on which treatment you need.

Is AgelessRx or Natural Cycles cheaper?

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Natural Cycles has the lower starting price (from $12.5/mo vs $25/mo for AgelessRx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do AgelessRx and Natural Cycles both offer?

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Both platforms treat Women's Health. AgelessRx covers 4 treatment categories total and Natural Cycles covers 1.

Still deciding?

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