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Calibrate vs Enhance.MD: Which Is Better?

Head-to-head comparison of Calibrate and Enhance.MD based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Calibrate scores higher overall in our independent evaluation (66.9/100 vs 66.9/100), leading on experience. Enhance.MD comes out ahead on value, reputation.

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Calibrate is a year-long metabolic-reset program pairing coaching and biomarker tracking with insurance-navigated branded GLP-1 prescribing — built for members who already have GLP-1 coverage, not cash-pay patients.

Visit Calibrate
67

Enhance.MD is a San Diego-based, physician-directed GLP-1 and NAD+ telehealth program that requires baseline and semiannual labs and video visits before and during treatment.

Visit Enhance.MD

Score Breakdown

DimensionCalibrateEnhance.MD
Overall Score66.9/10066.9/100
Trust & Safety30%76/10076/100
Value25%58/10060/100 ✓
Experience20%72/100 ✓68/100
Product Range15%60/10060/100
Reputation10%62/10065/100 ✓

At a Glance

Founded20192019
HeadquartersNew York, NYSan Diego, CA
Publicly tradedNoNo
Treatment categories12
Treatments listed25
Starting price$25/mo$169/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryCalibrateEnhance.MD
Weight Loss / GLP-1$25–$1350
Insurance-Navigated Branded GLP-1
$169
Microdose Tirzepatide

Calibrate

+Comprehensive year-long program combining 1:1 coaching, biomarker/lab review, and a connected smart scale alongside GLP-1 prescribing
+Insurance-navigation support aims to get members GLP-1 medication near a $25/month copay when commercial coverage applies
+Strong Trustpilot rating (4.5/5, ~1,200 reviews) with many members reporting 40-70+ lb losses
−Poor fit and high cost for cash-pay patients without GLP-1 insurance coverage — medication bills separately and can approach full brand retail (roughly $1,000+/month) if a plan doesn't cover it
−$199/month program fee requires a 3-month minimum commitment ($597) before month-to-month conversion
−Reports of 3+ week waits for medication-dose changes and inconsistent coach assignment session-to-session
Read the full Calibrate review →

Enhance.MD

+Requires baseline labs (CMP, lipids, TSH, HbA1c) before prescribing and repeats them every six months, included in the price
+Named medical director and named fulfilling pharmacies (Tru Meds Rx, Strive, Pharmacy Hub)
+Flat pricing across dose escalation, published before intake, with a full refund if found ineligible
−Billed every 28 days (13 charges a year), making effective annual cost higher than the monthly headline suggests
−Not available in 10 states, including GA, TN and MO
−Trustpilot complaints cite delayed or cancelled shipments and inconsistent results after pharmacy switches
Read the full Enhance.MD review →

Calibrate vs Enhance.MD — FAQ

Is Calibrate better than Enhance.MD?

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Calibrate scores higher overall in our independent evaluation (66.9/100 vs 66.9/100), leading on experience. Enhance.MD comes out ahead on value, reputation.

Is Calibrate or Enhance.MD cheaper?

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Calibrate has the lower starting price (from $25/mo vs $169/mo for Enhance.MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Calibrate and Enhance.MD both offer?

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Both platforms treat Weight Loss / GLP-1. Calibrate covers 1 treatment category total and Enhance.MD covers 2.

Still deciding?

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