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Defy Medical vs Effecty: Which Is Better?

Head-to-head comparison of Defy Medical and Effecty based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 66.8/100), leading on trust & safety, experience, product range, reputation. Effecty comes out ahead on value. Effecty has the lower entry price (from $55/mo vs $150/mo), so the better value depends on which treatment you need.

72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

Visit Defy Medical
67

New York-based cash-pay telehealth brand selling compounded GLP-1s, longevity injectables (NAD+, sermorelin, glutathione) and estradiol HRT with no membership fee and published tiered pricing.

Visit Effecty

Score Breakdown

DimensionDefy MedicalEffecty
Overall Score71.9/100 ✓66.8/100
Trust & Safety30%72/100 ✓60/100
Value25%60/10076/100 ✓
Experience20%78/100 ✓72/100
Product Range15%78/100 ✓66/100
Reputation10%80/100 ✓55/100

At a Glance

Founded20112024
HeadquartersTampa, FLNew York, NY
Publicly tradedNoNo
Treatment categories34
Treatments listed49
Starting price$150/mo$55/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDefy MedicalEffecty
Hormone Therapy$150–$250
Women's Bioidentical HRT
$55–$180
Estradiol (tablet, cream or patch) + Progesterone
Weight Loss / GLP-1$150–$250
GLP-1 Weight Loss (Semaglutide/Tirzepatide)
$80
Metformin

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

Effecty

+No membership fee, and prices are published per product and don't change with dose (semaglutide $130–$170/mo, tirzepatide $190–$235/mo)
+Card is held, not charged, until a prescription is written; shipping is free and expedited
+4.6/5 on Trustpilot across ~1,300 reviews, most citing fast support responses
−Only operating since November 2024; BBB rating is B with three closed complaints
−Visits are chat-only, and the compounding pharmacies are not named on the site
−Lowest advertised prices require 12-month prepayment; month-to-month runs 25–30% higher
Read the full Effecty review →

Defy Medical vs Effecty — FAQ

Is Defy Medical better than Effecty?

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Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 66.8/100), leading on trust & safety, experience, product range, reputation. Effecty comes out ahead on value. Effecty has the lower entry price (from $55/mo vs $150/mo), so the better value depends on which treatment you need.

Is Defy Medical or Effecty cheaper?

▾

Effecty has the lower starting price (from $55/mo vs $150/mo for Defy Medical). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Defy Medical and Effecty both offer?

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Both platforms treat Hormone Therapy, Weight Loss / GLP-1. Defy Medical covers 3 treatment categories total and Effecty covers 4.

Still deciding?

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