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Defy Medical vs He & She MD: Which Is Better?

Head-to-head comparison of Defy Medical and He & She MD based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 65.3/100), leading on trust & safety, experience, reputation. He & She MD comes out ahead on value, product range. He & She MD has the lower entry price (from $60/mo vs $150/mo), so the better value depends on which treatment you need.

72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

Visit Defy Medical
65

He & She MD is a Newport Beach-based men's and women's telehealth brand covering GLP-1s, longevity injectables, HRT, testosterone, hair loss and ED, with the lowest prices tied to long prepaid terms.

Visit He & She MD

Score Breakdown

DimensionDefy MedicalHe & She MD
Overall Score71.9/100 ✓65.3/100
Trust & Safety30%72/100 ✓58/100
Value25%60/10074/100 ✓
Experience20%78/100 ✓60/100
Product Range15%78/10084/100 ✓
Reputation10%80/100 ✓48/100

At a Glance

Founded20112025
HeadquartersTampa, FLNewport Beach, CA
Publicly tradedNoNo
Treatment categories37
Treatments listed413
Starting price$150/mo$60/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDefy MedicalHe & She MD
Hormone Therapy$150–$250
Women's Bioidentical HRT
$119
Testosterone (injection, gel, tablet)
Weight Loss / GLP-1$150–$250
GLP-1 Weight Loss (Semaglutide/Tirzepatide)
$99–$199
Compounded Semaglutide (injectable)
Sexual Health—$60–$96
ED Treatment (on-demand, daily, combination)

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

He & She MD

+Broad catalog covering compounded GLP-1s (injectable and oral), NAD+, sermorelin, glutathione, estradiol/progesterone HRT, testosterone, enclomiphene, hair loss and ED
+Names its dispensing pharmacies and the states where one partner cannot ship sterile compounds
+Low entry pricing on long terms: compounded semaglutide $99/mo on annual prepay, hair loss $79/mo, ED from $10/dose
−Site shows '4.8 Excellent' and 5.0 rating badges while its Trustpilot profile has zero reviews, so the ratings can't be verified
−Most headline prices require 3- to 12-month prepayment; month-to-month semaglutide is $199 and tirzepatide $299
−Platform terms allow a $15 fee per additional consult or lab-result interpretation on top of plan prices
Read the full He & She MD review →

Defy Medical vs He & She MD — FAQ

Is Defy Medical better than He & She MD?

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Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 65.3/100), leading on trust & safety, experience, reputation. He & She MD comes out ahead on value, product range. He & She MD has the lower entry price (from $60/mo vs $150/mo), so the better value depends on which treatment you need.

Is Defy Medical or He & She MD cheaper?

▾

He & She MD has the lower starting price (from $60/mo vs $150/mo for Defy Medical). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Defy Medical and He & She MD both offer?

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Both platforms treat Hormone Therapy, Weight Loss / GLP-1, Sexual Health. Defy Medical covers 3 treatment categories total and He & She MD covers 7.

Still deciding?

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